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    Default Testosterone its What separates the men from the boys

    Testosterone its What separates the men from the boys


    Remember what it was like to be young and full of testosterone? The day you used to wake up with a massive rock hard morning wood and at that time in your life hardly even knew what to do with it. How about the good old days when you could down a a package of Oreo’s with a gallon of milk without even gaining a single pound. What about that feeling of power and cockiness that was always present with you as a young man. Feeling like king of the world, no one could stand in your way and every woman on earth wanted to you because you were so perfect in every way. O yes thous sure where the days that have have long since past, Or have they? Are these days gone forever or can we regain some of these feelings once again?

    Testosterone is a lot more then just the pesky hormone that gets young boys into trouble. Its responsible for much more then a teenage boys rebellion well going through the changes of life. Thankfully we have learn much more about testosterone. Immaturity is what gets a young man in trouble, but testosterone is what separates the men from the boys.


    What is Testosterone?

    Testosterone is a steroid hormone from the androgen group and is also the MAIN hormone in a male’s body. In mammals, testosterone is primarily secreted by the testes of males and by the ovaries of females, while a tiny amounts is also secreted by the adrenal glands. It is the main male sex hormone and an anabolic steroid. Testosterone plays a key role in the development of male reproductive tissues which are the testis and prostate . Testosterone also promotes secondary sexual characteristics such as increased muscle and bone mass, hair growth, sexual behavior, development of the male genitals, increased glands, and sperm production . The adult human male body produces about ten times more testosterone than an adult human female body, but females are more sensitive to the testosterone. The brain and the bones are two important tissues in humans where the main effect of testosterone is carried out by way of aromatization to estradiol. Testosterone in the bones allows estradiol to accelerate maturation of the cartilage into bone, leading to closure of the epiphyses and end of growth. This in short explains why when young girls reach menarche, their growth starts to stunt. Estradiol serves as the most important feedback signal to the hypothalamus which triggers LH production. Testosterone is derived from cholesterol which is why people who suffer from cholesterol issues usually have low testosterone. Testosterone is a hormone that is triggered through the HPTA(hypothalamus). When the HPGA Axis is stimulated, the hypothalamus secretes gonadotropin-releasing hormone (GnRH), which on reaching the anterior pituitary, binds to the gonadotrophs and stimulates the release of both the luteinizing hormone (LH) and follicle stimulatinghormone (FSH) into the bloodstream. In the testes, testosterone is produced by the Leydig cells. The male generative glands additionally contain Sertoli cells which require testosterone for spermatogenesis. Like most hormones, testosterone is supplied to target tissues in the blood where much of it is transported bound to a specific plasma protein gondal, called the "sex hormone binding globulin" otherwise known as (SHBG). In males, LH binds to Leydig cells, stimulating production of the principal Leydig cell hormone, testosterone. Testosterone is secreted to the plasma and also carried to Sertoli cells by androgen binding protein (ABP). In Sertoli cells the 4 double bond of testosterone is reduced, producing dihydrotestosterone. A little more than 5% of testosterone is reduced to 5a-dihydrotestosterone (DHT) by the cytochrome through the enzyme 5a reductase. The conversion of testosterone to DHT leads to more sebaceous glands which in turn can leads to oily skin and acne. Less than 1% of testosterone is converted into estradiol by aromatase; also known as the CYP19A1 enzyme. Going back to the Sertoli Cells, in these cells it is regulated by FSH, again acting through a cAMP- and PKA-regulatory pathway. In addition, FSH stimulates Sertoli cells to secrete androgen-binding protein (ABP), which transports testosterone and DHT from Leydig cells to sites of spermatogenesis. There testosterone acts to stimulate protein synthesis and sperm development. Aromatase activity is also found in granulosa cells, but in these cells the activity is stimulated by FSH. Typically, then the cal-cell androgens produced in response to LH distribute to granulosa cells, whereas granulosa cell aromatase converts these androgens to estrogens. As granulosa cells mature they develop capable large numbers of LH receptors in the plasma membrane and become increasingly receptive to LH, increasing the amount of estrogen created from these cells. If not controlled it could lead to problems such as suppressed testosterone or gynecomastia due to the excess E2 levels. In a real short simplified expression; more SHBG leads to more Estrogen which leads to eventual negative effects.[2] Testosterone biosynthesis involves the cleavage of the sidechain of cholesterol by CYP11A, a mitochondrial cytochrome P450 oxidase with the loss of six carbon atoms to become pregnenolone ( the master precursor to all hormones). Next, two additional carbon atoms are removed by the CYP17A enzyme in the endoplasmic reticulum to give up a variety of carbon 19 steroide. In addition, the 3-hydroxyl group is oxidized by 3-ß-HSD to produce androstenedione. In the final and rate limiting step, the C-17 keto group androstenedione is condensed by 17-ß hydroxysteroid dehydrogenase to give way to testosterone.

    From reading this explanation of how testosterone is produced even the untrained eye can see a few easy ways one can increase there testosterone production. By increasing the master hormone pregnenolone, by increasing Lutinizing hormome, and or by lowering shbg are just some of the many ways one can begin to raise natural test levels and gain its benefits once again.

    Testosterone’s effect on blood Glucose Levels

    Androgen (specifically testosterone) deficiency has in recent times come to the forefront of the medical literature after being overlooked for decades. The popularity of hypogonadism is greater than previously thought. Important links are being developed and established in the literature between androgen deficiency and metabolic disorders. There is an important health impact related to metabolic syndrome, insulin resistance, type 2 diabetes, and eventually vascular disease and ERECTILE DYSFUNCTION! Low concentrations of testosterone are associated with insulin resistance and mixed up in hyperglycemia, hypertension, dyslipidemia, and an increased risk of vascular disease. The increasing number of individuals with obesity and low testosterone continue to show the same continuous pattern. I came across a study that consisted of over 6000 men, the men with higher serum levels of testosterone were at much lower risk of type 2 diabetes than men with lower levels of testosterone. [6] Low testosterone demonstrated to have adverse effects on insulin levels and sudden spurts in blood glucose levels. From research lower total testosterone levels leads to less insulin resistance which equates to more body fat distribution. Research indicates insulin is capable of stimulating testosterone production in vivo and at the same time reducing SHBG concentrations in both normal-weight and obese men. Since testosterone SIGNIFIGANTLY boosts insulin sensitivity it also gives leeway for glycemic control which allow one to EAT MORE CARBOHYDRATES without any problem whatsoever! This explains why you hear people saying “when I was a young dude I was able to pound two quarter pounders with NO problem, but now if I eat one quarter pounder I get extremely bloated, those were the good old days.”

    Aside from raining testosterone levels there are also powerful products that can have a outstanding positive effect on healthy insulin sensitivity. one such product of this nature would be Need2slin Need2slin and also

    Testosterone is the Fountain of Youth?

    Here is a small excerpt from a study that shows how testosterone declines within age which affects many organs and functions of the body. “Concentrations of sex steroids (especially testosterone) in serum decline progressively with age in men, as a result of complex alterations in reproductive physiology secondary causes of gonadal dysfunction and lifestyle factors and changes in the levels of binding proteins. Treatment of hypogonadism in younger and older men may result in an improvement in some relevant measures (e.g. osteopenia, sexual dysfunction, and muscle weakness). The average age of the study sample was 73 years of age and 389 (15%) were age 80 or older. Approximately 75% were Caucasian. Most reported themselves to be in excellent or good health compared with their peers. There were few current smokers, but a large proportion had smoked in the past. Alcohol consumption was four drinks per week on average. With the exception of race, distributions of these characteristics were not significantly different from those in the entire MrOS cohort. As men age; their SHBG levels rise and their total/free testosterone drops along their estradiol levels causing a loss in bone density. Higher BMI was related to lower testosterone and SHBG levels and higher estradiol concentrations. Total and free testosterone levels were slightly higher in men who rated their health status as excellent/good compared with those who rated it as fair/poor/very poor and were slightly higher in current smokers. Total testosterone levels were lower in Asian men and higher in African-American and Hispanic men. Free testosterone levels differed significantly by race (unadjusted P < 0.001; age- and BMI-adjusted P < 0.001) following the same trends as for total testosterone. No significant differences in total estradiol by race category were found. Unadjusted free estradiol differed slightly by race (P < 0.03) with whites having the lowest free estradiol concentration; however, after adjusting for age and BMI, the differences by race category diminished. SHBG concentrations differed by race category with Asian men having the lowest SHBG concentration and African-American and white men having the highest mean concentrations. Increasing levels of BMI positively, but slightly, influenced free estradiol. A larger proportion of free estradiol levels were related to free testosterone (positively) and SHBG (negatively) levels. Men with the highest free testosterone and lowest SHBG levels had free estradiol levels approxi-mately 3-fold higher than those with the lowest free testosterone and highest SHBG concentrations. The relationships between free testosterone and free estradiol, and between SHBG and estradiol, were linear. The concentrations of SHBG were slightly higher with greater age, were positively related to total testosterone levels, and were negatively associated with free estradiol levels. The rate of decline in free testosterone in older men is about 10% per decade. Higher SHBG levels were related to lower estradiol levels independent of free testosterone, suggesting that either SHBG has effects on estradiol levels over and above its testosterone-binding properties or that SHBG is actually a surrogate for other variables that may affect both SHBG and estradiol levels.” [7]

    Another study showed total testosterone of elderly men were inversely associated with weight, BMI, waist to hip ratio, systolic and diastolic blood pressure, fasting plasma glucose and/or serum insulin, HOMA-IR, triglycerides, CRP and leptin levels and positively related to HDL cholesterol and adiponectin levels. Total testosterone was slightly lower among men who consumed at least one alcohol drink daily, compared with those who drank less or not at all. Those who maintained a healthy BMI/LBM index maintained higher levels of total testosterone. The risk of death was significantly elevated for men in the lowest quartile of the total and bioavailable(free) testosterone distributions. Low total and bioavailable testosterone were each significantly associated with elevated 20-years decline period risk of Cardio Vascular Disease mortality and death due to respiratory disease but not from cancer or death due to other fatal causes. Renal, liver disease, stroke and pulmonary disease have also been linked to low total and free testosterone in older men. [8]

    Now both these articles conclude that it would be REALLY BENEFICIAL to take TRT (testosterone replacement therapy) if suffering from hypogonadism; which is primarily found in older men. Men who suffer from low testosterone do not get to reap the fruits of life as much as those who have higher levels of testosterone. Lots of older men use Testosterone replacement therapy to increase Rapid Eye Movement (REM) sleep in order to recover efficiently. There are studies that show that older men use testosterone replacement treatment for a better sense well of being. There are countless studies that show the distinct relationship between depression and testosterone levels. Depression and anxiety lead to lower levels of total and free testosterone, which would explain why certain SSRI’s have a noticeable effect on testosterone levels, serotonin along other neurotransmitters have been linked to effecting hormonal output. The one issue that some older men have with TRT is the higher increments in hemoglobin and hematocrit than young men after adjusting for testosterone levels. When older men take solid doses of testosterone studies show that they lose fat real quickly along with added muscle mass. These traits can be attributed to the ANABOLIC EFFECTS OF TESTOSTERONE! When men are receiving injections of testosterone; automatically nitrogen retention and protein synthesis capabilities rise much higher than the norm. This allows the individual the ability to consume more protein making anabolism even easier. Of course as age heightens; libido drops and old men lose the will or desire to engage in sexual activity. Testosterone also improves HDL which helps cholesterol in return providing proper blood flow to the corpus cavernosum allowing MAXIMUM erection strength. Testosterone replacement therapy has been touted to prevent osteoporosis through increasing the bone mineral density, when testosterone has a good ratio with estrogen it provides a nice sturdy foundation for bone structure, which again re-establishes the importance of testosterone to the male body. Older men as well as young men both deserve to enjoy the benefits of testosterone whether it be through endogenous or exogenous means.


    Sleep really does Testosterone some Good!


    Sleep really does Testosterone some Good!

    Recent research suggests that testosterone plays a role in regulating the CNS during sleep and vice versa. When sleeping in particularly during Rapid Eye Movement; testosterone levels raise dramatically, however as one awakes and encounters the typical stressors, testosterone levels gradually fall throughout the waking day. Rapid Eye Movement occurs in intervals of 90 minutes per stage of sleep, so if one were to sleep 8 hours, the individual could go through REM about 6 times throughout their sleep.Sleep deprivation results in a collection of widespread symptoms leading to alterations in catecholamine, hormone levels, and behaviors. In particular, sleep loss has been connected with altered regulation of the hypothalamic-pituitary adrenal axis, and it impairs gonadal function by producing a marked reduction in testosterone concentration. Subnormal testosterone concentrations may contribute to sexual inadequacy in humans, which may affect established or desired sexual relations. Sleep deprivation really negatively impacts over trained athletes, so those who compete as an athlete NEED to sleep in order for their body to maximize its hormonal production. When sleep is interrupted, the rise of testosterone is also interrupted causing a sudden drop, again REM is EXTREMLY important for the rise of testosterone during sleep. The endocrine system (specifically TESTOSTERONE) has a responsibility to maintain the metabolic processes needed for tissue repair, regeneration, and recovery. The circulating testosterone levels also are play a role in erection frequency, as time goes erection during REM lessens, which would also would explain the correlation of testosterone with libido. Sleep deprivation can lead to many sleep disorders, one common one is linked to testosterone, and this disorder is Sleep Apnea. Sleep Apneic males with severe breathing issues exhibited delayed peak testosterone concentrations. Men with severe obstructive sleep apnea show significantly reduced serum concentrations of free and total testosterone and of sex hormone-binding globulin (SHBG), though their LH levels are normal. This endocrine defect was reversed after 3 months of continuous positive airway pressure (CPAP) therapy. Males who take artificial amounts of testosterone also may have issues with sleep disturbances. Testosterone raises the nocturnal metabolic rate which can negatively affect the way one sleeps. Again realize these are people on cycle and not people with normal amounts of testosterone. Basically low or TOO high levels of testosterone can negate REM sleep which is why one should get blood work done to see where they stand. Many studies show that sleep deprivation leads higher cortisol levels and lower total/free testosterone levels, so I tell you all SLEEP AND SLEEP WELL! Higher testosterone leads to better sleep and more frequencies of REM. [4]

    For anyone needing help getting to sleep and staying a sleep at night Need2sleep is the perfect sleep aid Need 2 Sleep . Not only will it help get you to sleep faster but it helps get you into a deep sleep and keeps you there longer.

    Testosterone good for the Brain!



    Unlike what people may have thought due to the common “MeatHead” nickname given to muscular dumb guys, testosterone increases neurological function. An article I came across showed that as a result of decline in age, testosterone dropped, this led to increased risks for Alzheimer’s disease. Men with Alzheimer’s disease had lower levels of serum testosterone; this explains how both testosterone and estrogen have neuro-stimulative properties. Since Testosterone and Estrogen are neurosteroids this means they would also help prevent one from easily acquiring Addison’s disease. I even saw some research on PubMed that displayed testosterone’s importance in preventing Dementia, another “Slowing down of the Brain” disease. This is why dopamine in abundance has a positive effect on testosterone, although too much dopamine can cause over-stimulation leading to Schizophrenia. Some of you may be saying what does he mean by “neuro-stimulation”. When one ingests 200mg of caffeine, they are ingesting a bunch of stimulants which cause your neurotransmitters to rapidly fire, well certain sex hormones like testosterone act in this matter without the jittery feeling. This effect allows for better awareness, mental clarity, mental acuity, increased memory and so on. Caffeine has been proven to be effective in improving cognitive function, this goes to show you that when you compare caffeine to testosterone in the way they effect the brain, they both positive since they delay the effects of Dementia while allowing you to do more mental tasks







    So far we have seen that testosterone is good for the heart, respiratory system, brain function, blood glucose levels, cholesterol, bone density, sense of well being, and now we see testosterone’s anabolic properties. Here is a full abstract from another article that shows the anabolic benefits of testosterone:




    “Testosterone Therapy Prevents Gain in Visceral Adipose Tissue and Loss of Skeletal Muscle in Nonobese Aging Men

    C. A. Allan, B. J. G. Strauss, H. G. Burger, E. A. Forbes and R. I. McLachlan

    Prince Henry’s Institute (C.A.A., H.G.B., E.A.F., R.I.M.), Andrology Australia (C.A.A., R.I.M.), and Departments of Obstetrics and Gynecology (C.A.A., R.I.M.) and Medicine (B.J.G.S.), Monash University; and Clinical Nutrition and Metabolism Unit (B.J.G.S.), Monash Medical Centre, Monash University, Clayton, Victoria 3168, Australia

    Address all correspondence and requests for reprints to: Professor R. I. McLachlan, Prince Henry’s Institute, P.O. Box 5152, Clayton, Victoria 3168, Australia. E-mail: rob.mclachlan@princehenrys.org .

    Background: Trials of testosterone therapy in aging men have demonstrated increases in fat-free mass (FFM) and skeletal muscle and decreases in fat mass (FM) but have not reported the impact of baseline body composition.

    Objective: The objective of the study was to determine the effect, in nonobese aging men with symptoms of androgen deficiency and low-normal serum testosterone levels, of testosterone therapy on total and regional body composition and hormonal and metabolic indices.

    Methods: Sixty healthy but symptomatic, nonobese men aged 55 yr or older with total testosterone (TT) levels less than 15 nM were randomized to transdermal testosterone patches or placebo for 52 wk. Body composition, by dual-energy x-ray absorptiometry (FM, FFM, skeletal muscle) and magnetic resonance imaging (abdominal sc and visceral adipose tissue, thigh skeletal muscle, and intermuscular fat) and hormonal and metabolic parameters were measured at wk 0 and 52.

    Results: Serum TT increased by 30% (P = 0.01), and LH decreased by 50% (P < 0.001). Relative to placebo, total body FFM (P = 0.03) and skeletal muscle (P = 0.008) were increased and thigh skeletal muscle loss was prevented (P = 0.045) with testosterone therapy and visceral fat accumulation decreased (P = 0.001) without change in total body or abdominal sc FM; change in visceral fat was correlated with change in TT levels (r2 = 0.36; P = 0.014). There was a trend to increasing total and low-density lipoprotein cholesterol with placebo.

    Conclusion: Testosterone therapy, relative to placebo, selectively lessened visceral fat accumulation without change in total body FM and increased total body FFM and total body and thigh skeletal muscle mass”.



    PCT

    Now you guys can see that PCT (Post Cycle Therapy) is crucial to maintain gains and boost overall health. Many studies and blood panels have shown that PCT boosts liver cells, better ALT/LST levels, good cholesterol, proper testosterone to estrogen ratios, proper testosterone to cortisol ratios, solid IGF levels, proper hypothalamus function, proper brain function, good adrenals, good sense of well being, anti-oxidative, anti-cancerous, restoration of distorted blood vessels, proper maintenance of SHBG’s, bone and ligament/joint protection. As you can see there is plenty of reasons to have a PCT aligned besides maintaining gains. I have always been a firm believer of keeping testosterone and FREE testosterone levels up in order to keep vitality and overall quality of life. There are many way PCT protocols once could follow, I suggest do your own research and see what fits you best. Before/after a cycle and post PCT one should follow their body by doing hormonal/organ blood work to see where you stand.



    Supplements to boost testosterone Naturally!

    For years people have tried many ways to boost testosterone naturally for their specific means of interest. We had the tribulus error which was proven not to do much for the human male. Studies recently suggest that tribulus does boost androgen receptors within the brain which causes the rise in libido associated with supplementation of it. Now AI’s have been proven to raise LH output, increase both total and FREE testosterone while lowering estrogen. Formestane, 6bromo, Exemestane, arimadex all do the job in boosting total/free testosterone while blocking estrogen. 6-bromo and Formestane also block prolactin which allows for even MORE TOTA/FREE TESTOSTERONE boost. It is able to block prolactin by blocking the progesterone receptors at the same time it blocks the estrogen receptors. This would make Formestane an IDEAL otc AI while on Deca to avoid the unwanted “deca-dick”. The benefits of Formestane are really undeniable and should be a part of everyone’s artillery. Formestane also boosts IGF levels which means MORE MUSCLE GROWTH. Formestane can be used as a standalone, on cycle and during PCT! I did not mention ATD why, simple it has anti-androgen properties since it blocks the androgen receptor in the brain which leads to a lack of libido. It also does not boost testosterone levels as once thought, it appears that ATD provides false testosterone levels because ATD contains metabolites similar to Testosterone which cause the false high positives. Currently there are three reliable sources of Formestane: http://www.orbitnutrition.com/index....oducts_id=1239

    http://www.orbitnutrition.com/index....oducts_id=1553

    https://www.mrsupps.com/Product-Forma-Stanzol_26.aspx



    In this article: BCAAs raise T levels in bodybuilders

    We get to see how effective BCAA’s are in boosting testosterone since they reduce cortisol levels which rise during intense training. People have tried to deny the effectiveness of BCAA’s but as you can see it boosts testosterone. It only took 6 grams of BCAA’s for 4 weeks to see a noticeable difference. Now imagine taking the effects of Gear (Bovine super plasma blood serum) which is 3x more potent than standard BCAA’s, this means MORE TESTOSTERONE boost and MORE MUSCLE PRESERVATION! More testosterone leads to gains in MUSCLE MASS, STRENGTH, RECOVERY, and a BETTER YOU!

    HCGenerate brings a revolution to all herbal testosterone boosters because it contains a specific extract of Fadogia. Fadogia has shown to increase total testosterone levels at 6x more than that of some of the other popular herbal raws. It helps preserve and create new leydig cells which allows for more conversion of cholesterol to testosterone. Its ability to boost LH and testosterone dramatically makes it very comparable to HCG, which is why HCGenerate can be used on cycle to minimize shutdown; allowing PCT to be a breeze. HCGenerate also contains testofen which has been shown to DOUBLE FREE testosterone levels in HUMAN males. Free testosterone means that one is able to achieve the anabolic and androgenic effects of testosterone. When testosterone is not free; its USELESS because it cannot be used for any masculine purpose. So if one has really high testosterone but low free testosterone; they will not really reap the benefits that someone on a cycle of testosterone will receive. HCGenrate also contains Divanil which boosts FREE testosterone, lowers SHBG levels and boosts Nitric Oxide levels. HCGenerate is a MUST if you plan on using a SERM( Selective Estrogen Receptor Modulator) because SERM’s have been proven to raise SHBG’s which will drop free (useable) testosterone. Eventually high SHBG’s leads to not only low Free testosterone but Low total testosterone as seen with older individuals.

    7,8 Benzoflavone has always intrigued me because of its effectiveness. There are studies that show boosts testosterone by increasing GrRH release in which it stimulates GABAergic modulation and at the same time blocks estrogen due to its AI properties. It has an IC50 value of 70nm which is RIDICULOUS for an herbal raw, this explains why individuals who use this raw have dramatic boosts in testosterone with low LH levels. This raw converts LH to testosterone at a high rate while keep estrogen to a norm; giving it a nice 1-2 punch. I have seen my testosterone levels with bloodwork boost over 50% which is definitely impressive and lets me know it’s a must to add in my PCT with HCGenerate. Forma-stanzol again has what you need and contains 7,8 benzoflavone.

    https://www.mrsupps.com/Product-Forma-Stanzol_26.aspx

    Forged Steel has really caught my eye as of recently since it boosts libido DRAMATICALLY and boosts testosterone at the same time! Lets start off with the pumpkin seed powder that Forged Steel contains. Pumpkin seed powder has an abundance of Zinc which is crucial for maintaining testosterone efficiency, along bone density strength. Zinc protects the prostate from prostate enlargement which can be fatal. Zinc also is important for fertility in providing more counts of semen and semen mobility. Solid levels of Zinc also prevent testosterone from converting to DHT at a high rate which is what you want. Pumpkin Powder Seed has also been touted to raise FEMALE’S LIBIDO through her olfactory system. In essence, the scent of pumpkin makes a woman wetter in her “special place” which is what any testosterone filled dude wants! Companies are now starting to make colognes with Pumpkin seed powder extract to entice men to purchase their product. So its real simple, ingesting pumpkin seed leads to a concentration of pumpkin seed in the body, which leads to pore concentration, finally translates to women appeal and a good chance of GETTING LAID! Forged Steel also contains Muira Puama which decrease prolactin leading to increased TOTAL testosterone levels. It also boosts dopamine levels which leads to HARDER ERECTIONS and LASTING LONGER in the bedroom! Forged Steel is the REAL DEAL if you are looking for a quick boost prior to sexual activity. http://www.orbitnutrition.com/index....oducts_id=1399

    One more raw I want you all to witness is Mytosterone, this bad boy has been proven to boost testosterone by 60% while blocking estrogen by 9% and blocking DHT conversion by 20 plus %. Here is an excerpt to the study that showcases mytosterone:

    “BACKGROUND: Maintaining endogenous testosterone (T) levels as men age may slow the symptoms of sarcopenia, andropause and decline in physical performance. Drugs inhibiting the enzyme 5alpha-reductase (5AR) produce increased blood levels of T and decreased levels of dihydrotestosterone (DHT). However, symptoms of gynecomastia have been reported due to the aromatase (AER) enzyme converting excess T to estradiol (ES). The carotenoid astaxanthin (AX) from Haematococcus pluvialis, Saw Palmetto berry lipid extract (SPLE) from Serenoa repens and the precise combination of these dietary supplements, Alphastat(R) (Mytosterone(trade mark)), have been reported to have inhibitory effects on both 5AR and AER in-vitro. Concomitant regulation of both enzymes in-vivo would cause DHT and ES blood levels to decrease and T levels to increase. The purpose of this clinical study was to determine if patented Alphastat(R) (Mytosterone(trade mark)) could produce these effects in a dose dependent manner. METHODS: To investigate this clinically, 42 healthy males ages 37 to 70 years were divided into two groups of twenty-one and dosed with either 800 mg/day or 2000 mg/day of Alphastat(R) (Mytosterone(trade mark)) for fourteen days. Blood samples were collected on days 0, 3, 7 and 14 and assayed for T, DHT and ES. Body weight and blood pressure data were collected prior to blood collection. One-way, repeated measures analysis of variance (ANOVA-RM) was performed at a significance level of alpha = 0.05 to determine differences from baseline within each group. Two-way analysis of variance (ANOVA-2) was performed after baseline subtraction, at a significance level of alpha = 0.05 to determine differences between dose groups. Results are expressed as means +/- SEM. RESULTS: ANOVA-RM showed significant within group increases in serum total T and significant decreases in serum DHT from baseline in both dose groups at a significance level of alpha = 0.05. Significant decreases in serum ES are reported for the 2000 mg/day dose group and not the 800 mg/day dose group. Significant within group effects were confirmed using ANOVA-2 analyses after baseline subtraction. ANOVA-2 analyses also showed no significant difference between dose groups with regard to the increase of T or the decrease of DHT. It did show a significant dose dependant decrease in serum ES levels. CONCLUSION: Both dose groups showed significant (p = 0.05) increases in T and decreases in DHT within three days of treatment with Alphastat(R) (Mytosterone(trade mark)). Between group statistical analysis showed no significant (p = 0.05) difference, indicating the effect was not dose dependent and that 800 mg/per day is equally effective as 2000 mg/day for increasing T and lowering DHT. Blood levels of ES however, decreased significantly (p = 0.05) in the 2000 mg/day dose group but not in the 800 mg/day dose group indicating a dose dependant decrease in E levels.”

    Pretty impressive huh, I think a stack of Myodrol, HCGenerate and forma-stanzol would be INSANE providing that one will SIGNIFIGANTLY boost total/free testosterone, lower conversion of testosterone to DHT and estradiol, and preventing high aromatization. The only supplement that has a legit dose of mytosterone is myodrol by Axis Labs:

    http://www.orbitnutrition.com/index....oducts_id=1599



    Be it just to feel naturally more like a man or to help feel less like a woman during pct, Testosterone is what separates the men from the boys my friends and now you know how to get you some.




    Sources:
    1.Journal of Clinical Endocrinology & Metabolism Vol. 37, No. 1 148-151
    doi:10.1210/jcem-37-1-148

    2. Michael R. Waterman, Genes Involved in Androgen Biosynthesis and the Male PhenotypeDiane S. KeeneyDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tenn., USA Vol. 38, No. 5-6, 1992

    3.Steroid Hormones

    4. Monica Levy Andersen*, Sergio Tufik. The effects of testosteroneonsleep and sleepdisorderedbreathing in men:Its bidirectionalinteraction with erectile function. Sleep Medicine Reviews (2008) 12, 365e379 (http://www.sono.org.br/pdf/2008_Ande...ep_Med_Rev.pdf)

    5. ABDULAMAGED M. TRAISH, ANDRE GUAY, FARID SAAD. The Dark Side of Testosterone Deficiency: II. Type 2 Diabetes and Insulin Resistance. Journal of Andrology, Vol. 30, No. 1, January/February 2009. (The Dark Side of Testosterone Deficiency: II. Type 2 Diabetes and Insulin Resistance -- Traish et al. 30 (1): 23 -- Journal of Andrology)

    6. Ding EL, Song Y, Malik VS, Liu S. Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis. JAMA. 2006;295: 1288 –1299.[

    7. Testosterone and Estradiol among Older Men. The Journal of Clinical Endocrinology & Metabolism Vol. 91, No. 4 1336-1344

    Testosterone and Estradiol among Older Men -- Orwoll et al. 91 (4): 1336 -- Journal of Clinical Endocrinology & Metabolism

    8. Low Serum Testosterone and Mortality in Older Men. The Journal of Clinical Endocrinology & Metabolism Vol. 93, No. 1 68-75(2008)

    Low Serum Testosterone and Mortality in Older Men -- Laughlin et al. 93 (1): 68 -- Journal of Clinical Endocrinology & Metabolism

    9. Older Men Are as Responsive as Young Men to the Anabolic Effects of Graded Doses of Testosterone on the Skeletal Muscle. The Journal of Clinical Endocrinology & Metabolism Vol. 90, No. 2 678-688 (2005)

    10. Jones, T.H. (Barnsley/Sheffield) (eds): Advances in the Management of Testosterone Deficiency. Testosterone, Bone and Osteoporosis Front Horm Res. Basel, Karger, 2009, vol 37, pp 123-132 (2010)

    11. NEJM -- The Effects of Supraphysiologic Doses of Testosterone on Muscle Size and Strength in Normal Men

    12.Age-Related Testosterone Depletion and the Development of Alzheimer Disease. Vol.292 Nov.12, Sept. 22-29, 2004

    13. Behav Brain Res. 2010 Jan 20; 206(2): 216-22.

    14.Inhibition of human estrogen synthetase (aromatase) by flavones JT Kellis, Jr et al.Science, Sep 1984; 225: 1032 - 1034.

    15. Pumpkin Seeds Shown to Boost Sex Drive

    16. An open label, dose response study to determine the effect of a dietary supplement on dihydrotestosterone, testosterone and estradiol levels in healthy males. Journal of the International Society of Sports Nutrition 2008, 5:12 (2008)

    17. orbitnutrition.com

    18. mrsupps.com

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    LOTS of info in that one! Nice post!
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    DAMN, that's a lot of info! Pretty good stuff in there! Especially the piece about being good for the brain. Very interesting!

    Yay for pumpkin seeds!

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    no doubt. nice stuff.

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    Testosterone replacement therapy has been touted to prevent osteoporosis through increasing the bone mineral density,
    Interesting..
    I notice it says prevent. Do you know if any studies have been done where trt has helped aid someone who has osteoporosis and bone degeneration already?

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    ^ great question!

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    Quote Originally Posted by Gawd View Post
    Interesting..
    I notice it says prevent. Do you know if any studies have been done where trt has helped aid someone who has osteoporosis and bone degeneration already?
    Google endojournal bro, there is a couple of studies of people either taking testosterone or that have higher testosterone than others who have less chances of getting osteoporosis.
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    Also it will help to some extent with those with the disease but HGH/GH would need to be taken with it to preserve cartilage and rebuild bone.
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    Awesome info!





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    Quote Originally Posted by andrew732 View Post
    Also it will help to some extent with those with the disease but HGH/GH would need to be taken with it to preserve cartilage and rebuild bone.
    Cool thanks. Yea, this is what I was getting at. If it would help either by reversing or at the very least slowing down the disease progression.

    I'll look into it, see what I can find.

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    Good ol' TEST!
    STACKS = GREATNESS
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    Quote Originally Posted by andrew732 View Post
    Also it will help to some extent with those with the disease but HGH/GH would need to be taken with it to preserve cartilage and rebuild bone.
    I was going to say this. Ya deff gh for this would help.

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    Good read!!! Like Johnny 5 says "More Input!!!"

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    Testosterone is super important for men. I recommend any male take HCGenerate for a nice test boost. it is the best test booster i have ever taken and it is not even close. it is like comparing single A baseball players to major leaguers.
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    Nice analogy Rikishi!
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    This is an oustanding article to read. Thanks Nate

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    Great info throughout this thread! Thanks!
    225 lbs @ 10% after lean bulk - back to cutting!

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    Thanks for the good read...the orbit links are dead however just a fyi

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    great post forged steel is a nice product



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    That it is. Love that stuff

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    Quote Originally Posted by Gawd View Post
    Interesting..
    I notice it says prevent. Do you know if any studies have been done where trt has helped aid someone who has osteoporosis and bone degeneration already?

    i know it definately helped my arthritis!!! not only that but my eyesight has improved-before going on trt 8/28/08, my optometrist was ready to prescribe glasses.

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    well said mate

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    Quote Originally Posted by SonOfZeu$ View Post
    well said mate
    thanks, i looked at that post and kinda freaked at how long i have been on trt...the change it has made has been dramatic-and all positive!!!!

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    im glad to hear that, were you on try after you used aas or before? if i may ask

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    Quote Originally Posted by thebigt View Post
    thanks, i looked at that post and kinda freaked at how long i have been on trt...the change it has made has been dramatic-and all positive!!!!
    Yeah, posts from 2010 have been bumped up
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    Quote Originally Posted by SonOfZeu$ View Post
    im glad to hear that, were you on try after you used aas or before? if i may ask
    i had never used aas before trt...i think my test went in the tank after a high dosed run of cel's xtren...

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