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    Default Jay's MK-677 profile

    Infos about MK-677

    Type: Orally active growth hormone secretagogue
    Synonym: 2-Amino-2-methyl-N-[1-(1-methylsulfonylspiro[2H-indole-3,4'-piperidine]-1'-yl)-1-oxo-3-(phenylmethoxy)propan-2-yl]propanamide
    Mol. mass: 528.662 g/mol
    Half life: ~24h

    MK-677 is an orally active nonpeptide spiropiperidine previously demonstrated to be functionally indistinguishable in vitro and in vivo from GH-releasing peptide, a relatively selective GH secretagogue. MK-677 enhances the pulsatile release of GH, resulting in sustained elevations in IGF-I, and is well tolerated after oral administration in animals, healthy young men, and older men and women.

    Studies:
    Growth hormone secretagogue MK-677: no clinical ef... [Neurology. 2008] - PubMed result
    Results: Administration of MK-677 25 mg resulted in a 60.1% increase in serum IGF-1 levels at 6 weeks and a 72.9% increase at 12 months.

    Effects of an oral ghrelin mimetic on body composi... [Ann Intern Med. 2008] - PubMed result
    Results: Over 12 months, the ghrelin mimetic MK-677 enhanced pulsatile growth hormone secretion, significantly increased fat-free mass, and was generally well tolerated. Long-term functional and, ultimately, pharmacoeconomic, studies in elderly persons are indicated.

    MK-677, an Orally Active Growth Hormone Secretagogue, Reverses Diet-Induced Catabolism
    Results: In summary, we observed in this short-term study that oral administration of MK-677 reverses the protein catabolism caused by dietary caloric restriction. These data suggest that MK-677 may be useful as adjunctive therapy in certain catabolic states. MK-677 produced a peak GH response of 55.9 ng/ml after the first dose (day 8) and 22.6 ng/ml after a week of dosing (day 14) compared with peak GH responses of approximately 9 ng/ml (day 8) and approximately 7 ng/ml (day 14) with placebo (P < 0.05 for both comparisons). The degree of GH stimulation observed appears to be sufficient to improve nitrogen balance under the stress of caloric restriction. Whether the short-term anabolic effects observed in our volunteers apply also to patients who are catabolic because of certain acute or chronic disease states remains to be established. Future studies should attempt to determine whether the anabolic effects of MK-677 will persist with prolonged treatment, and whether they will be associated with clinical benefits, such as shorter hospital stay and accelerated convalesence.

    Treatment of obese subjects with the oral growth h... [J Clin Endocrinol Metab. 1999] - PubMed result
    Results: In conclusion, treatment with the oral GH secretagogue MK-677 affected circulating lipoproteins. The effects on serum apoA-1, apoE, triglycerides, and mean LDL particle diameter were transient. At study end, the LDL-C/HDL-C ratio was decreased. MK-677 treatment did not significantly affect serum Lp(a) concentrations at the present dose and administration protocol.

    The effects of MK-0677, an oral growth hormone sec... [J Am Geriatr Soc. 2004] - PubMed result
    Results: MK-0677 treatment increased serum IGF-I levels by 84% (95% confidence interval (CI)=63-107), compared with an increase of 17% (95% CI=8-28) on placebo. There were no significant differences between MK-0677 and placebo in improvement in functional performance measures or in the overall SIP-NH score. Although MK-0677 patients showed greater improvement relative to placebo in three of four lower extremity functional performance measures, in the physical domain of the SIP, and in the ability to live independently, these differences were not statistically significant.

    http://jcem.endojournals.org/content/86/3/1116.full.pdf
    Results: The primary results, except for BMD, are provided for month 12. MK-677, with or without alendronate, increased insulin-like growth factor I levels from baseline (39% and 45%; P < 0.05 vs. placebo). MK-677 increased osteocalcin and urinary NTx by 22% and 41%, on the average, respectively (P < 0.05 vs. placebo). MK-677 and alendronate mitigated the reduction in bone formation compared with alendronate alone based on mean relative changes in serum osteocalcin (−40% vs. −54%; P < 0.05, combination vs. alendronate) and reduced the effect of alendronate on resorption (NTx) as well (−52% vs. −61%; P < 0.05, combination vs. alendronate). MK-677 plus alendronate increased BMD at the femoral neck (4.2% vs. 2.5% for alendronate).

    Safety:
    MK-677 is generally well tolerated based on a review of patient discontinuations and serious adverse events. GH-mediated side effects were noted in the groups receiving MK-677, although adverse events resulting in discontinuation from the study were relatively infrequent. There were reports of fluid retention, for example, in groups receiving MK-677. These reports included weight gain and edema/swelling. Body weight increased 2–3 kg in groups receiving MK-677, whereas there was no significant change from baseline body weight in patients who received placebo.

    Elevations in serum glucose or PRL resulted in discontinuation in three patients each (all received MK-677). Modest increases in serum PRL (within the physiological range) and in fasting blood glucose were noted in patients who received MK-677, consistent with earlier experience with MK-677. Clinically significant increases in serum transaminase values (>3 times the upper limit of normal) resulted in study discontinuation in two patients (both received MK-677). There were no other significant differences among treatment groups in laboratory values.

    Dosage:
    Common dosage is 25mg ed
    Last edited by JayJo; 08-13-2011 at 07:30 AM.


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    Senior Member Mike2012's Avatar
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    excellent, thanks for the info! big help to my understand of what mk-677 actually is/does!

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    Senior Member ironmanZVW's Avatar
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    very promising, but I have to be skeptical because i tried both of the other popular sarms and they did jack****.
    Why be Clark Kent when I can be Superman?

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    Senior Member Mike2012's Avatar
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    Quote Originally Posted by ironmanZVW View Post
    very promising, but I have to be skeptical because i tried both of the other popular sarms and they did jack****.
    hopefully, since it seems the sarms worked for the majority of users, and mk-677 works through a completely different pathway, odd are still good

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    Quote Originally Posted by ironmanZVW View Post
    very promising, but I have to be skeptical because i tried both of the other popular sarms and they did jack****.
    This sucks! sarmssearch or GTG?


    Current discounts (i'm aware of):

    1. Mr. Supps: 10% off any purchase with discount code NEEDTO10
    2. Need To Build Muscle: 15% off any purchase with discount code NEEDTO139
    3. Ruthless Supplements: 10% off any purchase with discount code RUTHLESS10

    Feel free to pm or email me for any questions or comments.

  6. #6
    Senior Member Mike2012's Avatar
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    Quote Originally Posted by JayJo View Post
    This sucks! sarmssearch or GTG?
    Quote Originally Posted by ironmanZVW View Post
    I used g2g chem for the OSTA, Uniquemicals for the S4. Yea I was pretty disappointed by them, but no biggie man...win some you lose some lol.

    I THOUGHT i was running test, but it ended up being bunk...don't get me started lol. So I just started running oral winny tabs 50mg ed about 10 days ago, already leaning me out, and starting REAL test today lol.
    Sucks neither worked for you

  7. #7
    Senior Member ironmanZVW's Avatar
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    Quote Originally Posted by Mike2012 View Post
    Sucks neither worked for you
    haha yea, i'm just sticking to proven gear for the time being.
    Why be Clark Kent when I can be Superman?

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    i would love to see this logged!
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    Read Dat's thread on MK-677, It's called "Growth Hormone Secretagogues"

  10. #10
    Senior Member Mike2012's Avatar
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    JayJo, when do you plan to run it?

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    Will run it (hopefully) at the end of next week.


    Current discounts (i'm aware of):

    1. Mr. Supps: 10% off any purchase with discount code NEEDTO10
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    Feel free to pm or email me for any questions or comments.

  12. #12
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    Excellent, I'm many will be keenly watching! (well, reading)

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    Senior Member camthman's Avatar
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    subscribed
    The Iron is the best antidepressant I have ever found. There is no better way to fight weakness than with strength. Once the mind and body have been awakened to their true potential, it's impossible to turn back.

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    so what happend? no log?



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    Quote Originally Posted by ironmanZVW View Post
    very promising, but I have to be skeptical because i tried both of the other popular sarms and they did jack****.
    I see that your other post seemingly got deleted......luckily it lives on through a quote!

    You've gotta go SarsSearch SARMS bro. I felt the same way, but nothing compares to the purity and quality of SS. Try it and you wont be dissapointed.

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    SS is the sht

  17. #17
    Senior Member liffalot's Avatar
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    Quote Originally Posted by gymrat827 View Post
    SS is the sht
    The good ****.......not the bad ****.....

    Maybe we should say its the tits, since, you know, its not like there's a bad pair of tits.


    Feel free to PM me qith questions, I'm more than happy to help! Don't ask me about sources because I don't know any.

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    When it comes to top purity and quality, sarmssearch cuts no corners for sure




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