So it began that I would pick Tony up every day we trained and drove him to Speedy’s and home again. Tony was a very strong kid and a very quick study as well. I taught him what I had learned over the last seven years under John and Gary’s tutelage simply by doing the workouts with him. It was a great advantage for Tony because he avoided all the mistakes I had made. My first several years were all trial and error. More error than trial! This sped things up for him greatly and it showed in his physique very quickly. He put on lean mass and gained strength very quickly those first six months training with me. Years later Tony told me I was sometimes a dick in how I went about things with him. I was surprised he felt this way but in looking back he was right about that. I was hard on him sometimes and kind of a cocky dick at times as well. But to Toney’s credit he took it and persevered through it all!

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GW-501516 is a PPARδ modulator compound is currently being investigated for drug use by GlaxoSmithKline. It activates the same pathways activated through exercise, including PPARδ and AMP-activated protein kinase. It is being trialed as a potential treatment for a few conditions consisting mainly of obesity, diabetes, dyslipidemia and heart disease. GW-501516 has a synergistic effect when combined with the AMP-K agonist AICAR: the combination has been shown to significantly increase exercise endurance in animal studies more than 40%. And from My own experience yes it works my friends.

GW-50156 regulates fat burning through a number of different pathways which includes exercise mimetic effects.  It increases glycogen retention in skeletal muscle tissue while increasing muscle gene expression. This shift changes the body’s metabolism to allow for more fat burning and for energy instead of carbohydrates or protein as the source of fuel. This is why the main reason why it’s being looked into as a treatment for diabetes.  As it will not allow the patients to endure and overly catabolic state, thus allowing energy levels and health to be stable at all times. GW-501516 clearly demonstrates that it increases muscle mass while keeping glucose from touching the adipose tissue sort of like Need2Slin but need2slin does much more then just this. Treatments with GW-501516 have been shown to increase HDL cholesterol by up to 79% and the compound is now undergoing Phase II trials to improve HDL cholesterol in humans. We dive into its attributes further later in the article But again let me speak from personal experience. I did a test with this drug and Winstrol. I know for my self when I take wonstrol it always kills my cholesterol levels. Last time I took it I ended up with an HDL of ten and a LDL over two hundred and it only took less then 2 weeks for this to happen. So knowing this I took wintrol for 4 weeks and also took GW-501516 along with it and I was amazed at the results. My cholesterol levels were BETTER at the end of the 4 week trial. So if cholesterol is of concern for you then you need to get some of this stuff my friend because trust me it works.

Concerns had been raised right before the 2008 Beijing Olympics that GW-501516 could be used by athletes as a performance enhancing drug which was not detectable nor tested for during the doping test. The main reason why athletes would use it is because of the increase in endurance through the increase of glycogen storage leading to increased muscular endurance, again ring a bell. Need2Slin does THE SAME THING! GW-501516 has yet to be label a controlled or banned substance by any national drug enforcement agency including Wada. Obviously no one will test positive for this drug, so if I were an Olympic athlete looking for a boost; this would be at the top of the list considering its much outweighed pros over cons. Any Athletes looking for a edge can use this drug and never have to worry about popping hot. They can not test for it my friends so you are golden. Some new testing is coming out in the next 3-5 years that will allow them to basically test your DNA to see if your bosy as been drug altered in anyway but this is years in the making. For now you are safe to take GW-501516 and not have to worry about popping hot.

Injecting GW501516 is like injecting a cardio session LOL

The benefits of endurance exercise on general health make it desirable to identify orally active agents that would mimic or potentiate the effects of exercise to treat metabolic diseases. Although certain natural compounds, such as reseveratrol, have endurance-enhancing activities, their exact metabolic targets remain elusive. We therefore tested the effect of pathway-specific drugs on endurance capacities of mice in a treadmill running test. Researchers found that PPARbeta/delta agonist and exercise training synergistically increase oxidative myofibers and running endurance in adult mice. Because training activates AMPK and PGC1alpha, they then tested whether the orally active AMPK agonist AICAR might be sufficient to overcome the exercise requirement. Unexpectedly, even in sedentary mice, 4 weeks of AICAR treatment alone induced metabolic genes and enhanced running endurance by 44%. These results demonstrate that AMPK-PPARdelta pathway can be targeted by orally active drugs to enhance training adaptation or even to increase endurance without exercise.  Now how does this peptide cause mice to lose weight without activity? Simple, the Activation of PPARβ/δ by GW501516 in skeletal muscle cells induces the expression of genes involved in preferential lipid utilization, β-oxidation, cholesterol efflux, and energy uncoupling. In addition, the treatment of muscle cells with GW501516 increases apolipoprotein-A1 specific efflux of intracellular cholesterol, thus identifying this tissue as an important target of PPARβ/δ agonists. Interestingly, fenofibrate induces genes involved in fructose uptake, and glycogen formation. In contrast, rosiglitazone-mediated activation of PPARγ induces gene expression associated with glucose uptake, fatty acid synthesis, and lipid storage. Furthermore, we show that the PPAR-dependent reporter in the muscle carnitine palmitoyl-transferase-1 promoter is directly regulated by PPARβ/δ, and not PPARα in skeletal muscle cells in a PPARγ coactivator-1-dependent manner. This study demonstrates that PPARs have distinct roles in skeletal muscle cells with respect to the regulation of lipid, carbohydrate, and energy homeostasis. Overall the peptide GW501516 (PPARβ/δ agonists) would increase fatty acid catabolism, cholesterol efflux, and energy expenditure in muscle, and speculate selective activators of PPARβ/δ may have therapeutic utility in the treatment of hyperlipidemia, atherosclerosis, and obesity.  (Dressel et al. 17 (12): 2477).. However I would advice only using this drug orally IMO..

Proof that GW5010516 increases insulin sensitivity

Elevated plasma free fatty acids cause insulin resistance in skeletal muscle through the activation of a constant chronic inflammatory process. This process involves nuclear factor (NF)-kappaB activation as a result of diacylglycerol (DAG) accumulation and following protein kinase Ctheta (PKCtheta) phosphorylation. At present, it is unknown whether peroxisome proliferator-activated receptor-delta (PPARdelta) activation prevents fatty acid-induced inflammation and insulin resistance in skeletal muscle cells. In C2C12 skeletal muscle cells, the PPARdelta agonist GW501516 prevented phosphorylation of insulin receptor substrate-1 at Ser(307) and the inhibition of insulin-stimulated Akt phosphorylation caused by exposure to the saturated fatty acid palmitate. This latter effect was reversed by the PPARdelta antagonist GSK0660. Treatment with the PPARdelta agonist enhanced the expression of two well known PPARdelta target genes involved in fatty acid oxidation, carnitine palmitoyltransferase-1 and pyruvate dehydrogenase kinase 4 and increased the phosphorylation of AMP-activated protein kinase, preventing the reduction in fatty acid oxidation caused by palmitate exposure. In agreement with these changes, GW501516 treatment reversed the increase in DAG and PKCtheta activation caused by palmitate. Consistent with these findings, PPARdelta activation by GW501516 blocked palmitate-induced NF-kappaB DNA-binding activity. These findings indicate that PPARdelta attenuates fatty acid-induced NF-kappaB activation and the subsequent development of insulin resistance in skeletal muscle cells by reducing DAG accumulation. The results of the study clearly demonstrate that PPARdelta activation is a pharmacological target to prevent insulin resistance. (Endocrinology 2010 Apr; 151(4) :1560-9.)

The peroxisome proliferator-activated receptor δ (PPARδ) regulates the expression of genes involved in cellular lipid and cell energy metabolism in many metabolically active tissues, such as liver, muscle, and fat, and plays a role in the cellular response to stress and environmental stimuli. The particular role of PPARδ in insulin-secreting β-cells, however, is not well understood; we recently identified the cell-specific role of PPARδ on mitochondrial energy metabolism and insulin secretion in lipotoxic β-cells. After treatment of HIT-T15 cells, a syrian hamster pancreatic β-cell line, with high concentrations of palmitate and/or the specific PPARδ agonist GW501516, we detected the gene expression changes for transcripts, such as peroxisome proliferator-activated receptor gamma co-activator 1 (PGC-1α), nuclear respiratory factor 1 (NRF-1), mitochondrial transcription factor A (mtTFA), the protein levels of the mitochondria uncoupling protein 2 (UCP2), mitochondrial morphology, the insulin secretion capacity and ATP/ADP ratio. Our results show that GW501516 treatment promoted generation of mitochondrial ATP, as well as expression levels of PGC-1α, NRF-1 and mtTFA, decreased basal insulin secretion, but had no effect on glucose-stimulated insulin secretion (GSIS), increased amounts of UCP2 and changed ATP-to-ADP ratio, improved mitochondrial morphology in palmitate-treated β-cells. GW501516-induced activation of PPARδ enhanced mitochondrial energy metabolism, but also promoted a concomitant mitochondrial uncoupling and resulted in decreased basal insulin secretion and restricted GSIS; this observation indicated the possible action of a protective mechanism responding to the alleviation of excessive lipid load and basal insulin secretion in lipotoxic β-cells. (Volume 343, Numbers 1-2, 249-256, DOI: 10.1007/s11010-010-0520-8) As you can see this peptide has a profound effect on the liver and pancreas resulting in lower blood sugar and controlled insulin output.

GW501516 prevents brain aging.

Brain inflammation plays a central role in numerous brain pathologies, including multiple sclerosis (MS). Microglial cells and astrocytes are the effector cells of neuroinflammation. They can be activated also by agents such as interferon-γ (IFN-γ) and lipopolysaccharide (LPS). Peroxisome proliferator-associated receptor (PPAR) pathways are involved in the control of the inflammatory processes, and PPAR-β seems to play an important role in the regulation of central inflammation. In addition, PPAR-β agonists were shown to have trophic effects on oligodendrocytes in vitro, and to give partial protection in experimental autoimmune encephalomyelitis (EAE), an animal model of MS. In the present work, a three-dimensional brain cell culture system was used as in vitro model to study antibody-induced demyelination and inflammatory responses. GW 501516 is a specific PPAR-β agonist that researchers chose to  examine for its capacity to protect from antibody-mediated demyelination and to prevent inflammatory responses induced by IFN-γ and LPS. GW 501516 decreased the IFN-γ-induced up-regulation of TNF-α and iNOS in accord with the proposed anti-inflammatory effects of this PPAR-β agonist. However, it increased IL-6 m-RNA expression. In demyelinating cultures, reactivity of both microglial cells and astrocytes was observed, while the expression of the inflammatory cytokines and iNOS remained unaffected. Furthermore, GW 501516 did not protect against the demyelination-induced changes in gene expression.  This suggests that the protective effects of PPAR-β agonists observed in vivo can be attributed to their anti-inflammatory properties rather than to a direct protective or trophic effect on oligodendrocytes.  We all know that both alzheimer’s and Dementia are caused by chronic inflammation within the brain. Further research is still needed but this peptide displays promise in preventing the aging of the brain. (Journal of Neuroinflammation 2009, 6:15 doi:10.1186/1742-2094-6-15)

GW501516 helps prevent the onset of Diabetes

In contrast to the well-established roles of PPARgamma and PPARalpha in lipid metabolism, little is known for PPARdelta in this process. We show here that targeted activation of PPARdelta in adipose tissue specifically induces expression of genes required for fatty acid oxidation and energy dissipation, which in turn leads to improved lipid profiles and reduced adiposity. Importantly, these animals are completely resistant to both high-fat diet-induced and genetically predisposed (Lepr(db/db)) obesity. As predicted, acute treatment of Lepr(db/db) mice with a PPARdelta agonist depletes lipid accumulation. In parallel, PPARdelta-deficient mice challenged with high-fat diet show reduced energy uncoupling and are prone to obesity. In vitro, activation of PPARdelta in adipocytes and skeletal muscle cells promotes fatty acid oxidation and utilization. Our findings suggest that PPARdelta serves as a widespread regulator of fat burning and identify PPARdelta as a potential target in treatment of obesity and its associated disorders. (Cell. 2003 Apr 18;113(2):159-70. PMID:12705865)

PPAR Agonist help prevent Dyslipidemia

In vitro and in vivo genetic and pharmacological studies have demonstrated PPARα regulates lipid catabolism. In contrast, PPARγ regulates the conflicting process of lipid storage. However, relatively little is known about PPARβ/δ in the context of target tissues, target genes, lipid homeostasis, and functional overlap with PPARα and -γ. PPARβ/δ, a very low-density lipoprotein sensor, is abundantly expressed in skeletal muscle, a major mass peripheral tissue that accounts for approximately 40% of total body weight. Skeletal muscle is a metabolically active tissue, and a primary site of glucose metabolism, fatty acid oxidation, and cholesterol efflux. Surprisingly, the role of PPARβ/δ in skeletal muscle has not been investigated. We utilize selective PPARα, -β/δ, -γ, and liver X receptor agonists in skeletal muscle cells to understand the functional role of PPARβ/δ, and the complementary and/or contrasting roles of PPARs in this major mass peripheral tissue. Activation of PPARβ/δ by GW501516 in skeletal muscle cells induces the expression of genes involved in preferential lipid utilization, β-oxidation, cholesterol efflux, and energy uncoupling. Furthermore, we show that treatment of muscle cells with GW501516 increases apolipoprotein-A1 specific efflux of intracellular cholesterol, thus identifying this tissue as an important target of PPARβ/δ agonists. Interestingly, fenofibrate induces genes involved in fructose uptake, and glycogen formation. In contrast, rosiglitazone-mediated activation of PPARγ induces gene expression associated with glucose uptake, fatty acid synthesis, and lipid storage. Furthermore, we show that the PPAR-dependent reporter in the muscle carnitine palmitoyl-transferase-1 promoter is directly regulated by PPARβ/δ, and not PPARα in skeletal muscle cells in a PPARγ coactivator-1-dependent manner. This study demonstrates that PPARs have distinct roles in skeletal muscle cells with respect to the regulation of lipid, carbohydrate, and energy homeostasis. Moreover, we surmise that PPARβ/δ agonists would increase fatty acid catabolism, cholesterol efflux, and energy expenditure in muscle, and speculate selective activators of PPARβ/δ may have therapeutic utility in the treatment of hyperlipidemia, atherosclerosis, and obesity.  (Dressel et al. 17 (12): 2477)

GW5015016 decreases chances of Heart Disease

The peroxisome proliferator-activated receptors (PPARs) are dietary lipid sensors that regulate fatty acid and carbohydrate metabolism. The hypolipidemic effects of the fibrate drugs and the antidiabetic effects of the glitazone drugs in humans are due to activation of the alpha (NR1C1) and gamma (NR1C3) subtypes, respectively. In macrophages, fibroblasts, and intestinal cells, GW501516 increases expression of the reverse cholesterol transporter ATP-binding cassette A1 and induces apolipoprotein A1-specific cholesterol efflux. When dosed to insulin-resistant middle-aged obese rhesus monkeys, GW501516 causes a dramatic dose-dependent rise in serum high density lipoprotein cholesterol while lowering the levels of small-dense low density lipoprotein, fasting triglycerides, and fasting insulin. These results suggest that PPARdelta agonists may be effective drugs to increase reverse cholesterol transport and decrease cardiovascular disease which is typically associated with the metabolic syndrome X. (Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5306-11. Epub 2001 Apr 17. PMID:11309497)

As for as dosing is concerned, I recommend 5-20mgs once a day, and research on HUMANS has clearly shown that 5mg is sufficient to elicit its intended effects. I really don’t understand why this peptide is not as common as it should be. Its exercise in a vial LMAO.

Now onto the fun stuff guys. Dosing, stacking and uses for this drug. Many people would start out at a 5mg a day dose and I think this is fine but I would also add in another 5mg dose pre work out as well on work out days at the very least if not just run it 10mg every day IMO. IMO one could use this during pct allow you to keep calories high and not gain to much fat which is often what happens. I think its also great in combo with Sarms S4 as a bridge between cycles but I am against using S4 during pct. SO only use it after pct and you are sure you have recovered. Now here is the best part GW-501516 can be used with Drugs like winstrol, Beastdrol, and other orals that would cause problems with cholesterol and this would help keep the numbers to a minimum. High blood pressure, nose bleeds and high cholesterol is common with a lot of oral steroids and this drug will help in the sense that it will lower cholesterol levels..

That is all for now my friend. Always remember to Keep Killing that sh*t!!!!!

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“Consider the case of Darren Meade, who in 2010 was working as interim CEO at a California-based company. In an effort to address a number of negative comments (about both himself and his company [Progenex]) posted online…he discovered the company wanted to sell illegal hacker code to scrub negative comments from the web…”

Excerpt – this part is especially heinous and disgusting – it’s Adam Zuckerman, the owner of Progenex, talking about how he wants to use his hacking program to extort parents:

“I would love to run an underground campaign that says, ‘Google is trying to destroy your reputation,’” an executive on the call is heard saying. “I like the idea of, ‘the more popular you are, the more dangerous it is,’ and giving people the scare tactic of, ‘the more exposure you have … the faster it is for your enemies to attack you.’”

“I think there’s a whole other campaign where we can break the parents,” the executive continued. “Send them a picture of their kid with a gun in his mouth — Google did it. ‘Little Johnny is going to commit Google-cide. Can you stop it?’”

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Albuterol Outperforms Clen in the StrengthDepartment Clenbuterol does not match up withAlbuterol in the area of strength gains due to the fact that it dosedependently inhibits action potential firing within skeletal musclefibers. This is not directly stimulated byinnate Beta-2 stimulant activities. Reason being is that Clenbuterolblocked sodium currents in rat skeletal muscle fibers and in tsA201 cellstransfected with the human channel isoform, whereas Albuterol did not. Theeffects of clenbuterol were independent of beta-adrenoceptor stimulation.Instead, clenbuterol structure and physicochemical characteristics as well asblocking properties resembled those of local anesthetics, suggesting directbinding to the channels. (Mol Pharmacol. 2003Mar;63(3):659-70.)

Albuterol GREAT For Cholesterol!!!!!! This is because Albuterol showssignificant benefits to cholesterol as it works to lower total cholesterol,specifically LDL (the bad stuff) while at the same time elevating HDL. A study evaluated theeffects of a beta(2)-agonist, albuterol, on serum lipids and carbohydratehomeostasis in eight healthy nonsmoking men aged 24 to 61 years. Collection offasting blood samples was completed in duplicate on separate days at baseline,during 14 days of oral albuterol administration (Proventil Repetabs, 8 mg twicedaily; Schering Pharmaceuticals, Kenilworth, NJ) and during a 7-day washoutperiod. Carbohydrate homeostasis was evaluated using the minimal modeltechnique at the end of the baseline and albuterol periods. Fasting glucose andinsulin, intravenous glucose tolerance, acute insulin response to intravenousglucose (AIRg), insulin sensitivity (Si), and glucose effectiveness (Sg) werenot significantly changed during albuterol administration. Significantalterations (P < or = .02) were observed in total cholesterol ([TC] 9.1%+/ 2.5%), low-density lipoprotein cholesterol ([LDL-C] 15.0% +/ 2.9%), andhigh-density lipoprotein cholesterol ([HDL-C] +10.4% +/- 3.2%) concentrations,as well as the TC/HDL-C (-17.4% +/- 2.6%) and LDL-C/HDL-C (-22.9% +/- 2.4%)ratios. During washout, TC and LDL-C returned to baseline levels, whereas HDL-Cremained elevated by 5.8% +/- 2.4% (P < .05). Thus, albuterol administrationwas associated with favorable changes in the serum lipid profile without markedimpairment of glucose tolerance or its physiologic determinants. (Metabolism.1996 Jun;45(6):712-7) Another study I came upon was done on thirteenpatients for a total of 3 months. All patients had bronchial asthma and weretreated with 2 mg salbutamol three times daily (one patient with 4 mg threetimes daily). The concentrations of serum total cholesterol and LDL-cholesterolwere slightly but not statistically significantly higher after 3 months withsalbutamol than before the medication. The serum HDL-cholesterol andtriglyceride concentrations remained constant during the therapy. Serum freefatty acid levels decreased slightly but not significantly during the therapy.Treatment with salbutamol did not elevate plasma free fatty acid levels, whichmay have arrhythmic effects. The results indicate that beta 2-adrenergicstimulation has no effect on basal serum lipid levels. So besides beinganabolic, its also good for cholesterol sounds like a winner to me. This makesit ideal to take on cycle because we all know the negative affects AAS can havecholesterol, you literally get the best of both worlds while on Albuterol.

Usual dosing should start at around 1-2 4mg tabletsper day and will up the dosage as their individual tolerance allows for. Somepeople get up to 24mgs a day because of a high tolerance to the drug. Veterans will often take their temperature anduse an increase in temperature as a measure to what effect the drug is having.It is important to note that after 2-3 weeks, the receptors will become burnout to stimulation. I recommend 25mgs of Benedryl to up regulate the receptorsback into full gear which should allow you to take just one week off as opposedto the normal 2 on and 2 off protocol. Sides The most commonly noted side effects are fine tremor,anxiety,headache,muscle cramps, dry mouth,and palpitation. Other symptoms may include tachycardia,arrhythmia,flushing, myocardial ischemia, shaking of hands orjitters, shortness of breath, insomnia and impulsive behaviour. Rarelyoccurring, but of importance, are allergic reactions of paradoxicalbronchospasm,urticaria,angioedema,hypotension,and collapse. High doses may cause hypokalaemiawhich are of concern in patients with renal failureand those on certain diuretics and xanthinederivatives. High doses can also cause fatal heart complications due tooverstimulation of the CNS. Detectiontime of AlbuterolAlbuterol has a half life of about 4 hours which iswhy bodybuilders will take 3 divided dosages. Only slow releasing tabs willallow 12 hour dosing intervals. Urinary salbutamol concentrations arefrequently measured in competitive athletic commissions, for which a levels exceedingthat of 1000 μg/L is considered to be a form of cheating aka performanceenhancement. The window of detection for urine testing is on the order of just24 hours, given the relatively short elimination half-life of the drug. Albuterolboosts athletic performanceThe present study examined whetheroral short-term administration of salbutamol (Sal) aka Albuterol modifiesperformance and selected hormonal and metabolic variables during submaximalexercise. Eight recreational male athletes completed two cycling trials at80-85% peak O(2) consumption until exhaustion after either gelatin placebo(Pla) or oral Sal (12 mg/day for 3 wk) treatment, according to a double-blindand randomized protocol. Blood samples were collected at rest, after 5, 10, and15 min, and at exhaustion to determine growth hormone (GH), cortisol, testosterone,triiodothyronine (T 3), C peptide, free fatty acid (FFA), blood glucose,lactate, and blood urea values. Time of cycling was significantly increasedafter chronic Sal intake (Sal: 30.5 +/- 3.1 vs. Pla: 23.7 +/- 1.6 min, P <0.05). No change in any variable was found before cycling except a decrease inblood urea concentration and an increase in T(3) after Sal that remainedsignificant throughout the exercise test (P < 0.05). Compared with rest,exercise resulted in a significant increase in GH, cortisol, testosterone,T(3), FFAs, and lactate and a decrease in C peptide after both treatments withhigher exercise FFA levels and exhaustion GH concentrations after Sal (P <0.05). Sal but not Pla significantly decreased exercise blood glucose levels.From these data, short-term Sal intake did appear to improve performance duringintense sub maximal exercise with concomitant increase in substrateavailability and utilization, but the exact mechanisms involved need furtherinvestigation. (J Appl Physiol. 2000Aug;89(2):430-6.) Soif you are looking for a replacement to Clen, Albuterol is your go to drug asit is shorter acting which should yield less overall sides. It also providesgreater strength than clen, while providing great fat loss and being morebeneficial to one’s lipids. Anyone on cycle should really consider Albuterolover a lot of fat burners and that is a fact. Also remember that this drug willprovide gains in endurance and increase breathing capacity during training,unlike what some notice with Clen. Albuterol may not be as known as Clen but it is definitely what I call agolden nugget trapped in a sealed mine. I would reconsider Albuterol for your next physique improving cycle.

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Trenbolone is a classified schedule III drug in the United States; which means that it is illegal. It is from the 19-nor family of anabolic steroids just as deca is. The 19-nor stands for the fact that the testosterone molecule was changed at the 19^th position to make it into the new and more potent compound. It was originally an anabolic androgic steroid developed and used by veterinarians on livestock to increase muscle growth and appetite and later would make its way to the chemical athlete’s world.  The farmers clearly knew that these anabolics were the key to bigger and better breeds, allowing for faster income as well.  On the average farmers sell cattle that have less than 28% EBF, they will not exhibit enough finish to reach a USDA quality grade of low choice. The majority of cattle need to have at least 28.5-29.5% EBF in order to grade to their genetic potential.

Therefore, all these factors need to be taken into consideration when choosing an effective implant (Trennobolone acetate) strategy which include feed costs, animal costs, quality grade, genetics, economic advantages of weight (live & carcass), production goals, and carcass goals. There are trade-offs to all the above and implants can help you achieve your goals and benefit you economically in all circumstances.

The chart from this link (http://www.depts.ttu.edu/afs/implantdb/dbhome/Revalor%20Tech%20Bulletin%2012.pdf) displays that cattle had the fastest rate of growth while on Finaflex pellets with the least amount of money spent as well. Now if you are a farmer chances are you are going to tell yourself, I am going to take this option instead of the old fashion grass fed way. The study also noted that when taking Tren with estradiol, the weight gain was more proficient. Of course bodybuilders don’t want to take estradiol, but taking tesostosterone will allow for aromatization which in turn will increase the body’s estradiol production leading to more muscle gain. This one of the reasons why the Test-Tren stack is so popular besides the fact that testosterone helps the impaired libido from Tren.

Benefits of Tren

In many people’s eyes, tren is pound for pound the strongest compound for pure gains and stacks well with anything; although some may argue that it’s a No No while on nanodrolone aka deca however I have ran both successfully with no more or less problems than running them separate . Trenbolone significantly increases nutrient efficiency along mineral/vitamin absorption. Feed efficiency is the measurement of how much of an animal diet is converted into meat, and the more consumption of food it takes to finalize this meat, the lower the value. On the other hand, the less food consumed by the animal to finalize the meat; the higher the value/efficiency. As mentioned in the study above, Cattle given trenbolone gained high quality weight without having their diet changed; leading to improved feed efficiency. This is music to the ears of every bodybuilder because Tren guarentees that every calorie you eat will go to some value of nutrition. This allows for better utlilization of the nutrition you intake to go to the muscles and organs of the body. This would explain why the cattle grew so rapidly while on Finaflex pellets.

Trenbolone is one of the few anabolic androgenic steroids that can lead to fat loss without change in diet, and it also has scholarly literature stating so.  This makes it perfect on a recomp as you will lose all fat needed but pack on dense muscle at the same time, don’t get me wrong; you can still use it for other goals including bulking and cutting.

Like most all anabolic androgenic steroids the Trenbolone hormone greatly promotes nitrogen retention in the muscles, increases red blood cell count and dramatically reduces and blocks glucocorticoid steroids aka the stress hormone cortisol; this hormone destroys muscle and increases fat storing hormones. This also means that you can do all the cardio you need to lose fat without having to worry about losing your muscle gains. Dieting can also place major stress on the mind and body leading to more cortisol, but Tren can help cease the cortisol release. Tren sounds ideal on a cut if you ask me. Increased nitrogen retention also means increased nutrient deliver to the muscles allowing for more glycogen retention. More glycogen retention leads to better workouts and a fuller look.

As is with nearly all anabolic androgenic steroids the Trenbolone hormone can greatly promote cell repair and regeneration, which will speed up the healing process in the body. The main reason why you experience growth on anabolics is because your recovery times goes up allowing you to become faster stronger. The more weight with frequency you can lift, the more and faster you will grow. One of the reasons why Tren is so good at increasing recovery time is the fact that it significantly increases the body’s natural production of the potent anabolic hormone IGF-1. Tren also causes muscle satellite cells to be more responsive to IGF-1 and other growth factors. The amount of DNA per muscle cell will also experience a significant increase. For these reasons adding Igf-lr3 into a tren cycle is a no brainer.

Trenbolone severely binds to the androgen receptors therefore increasing growth of muscle mass and melting fat away. This is important, because the stronger a steroid binds to the androgen receptor the better that steroid works at activating androgen receptor’s dependant mechanisms of muscle growth. There is also strong supporting evidence that androgens which bind very firmly to the androgen receptor also help in shedding fat. The androgen receptors are like locks and the androgens are like different keys. Some keys open the locks much better than others. This is does not mean that AR-binding is the only way that steroids work. There are anabolics that barely have any considerable binding to the AR and yet display great capability to build muscle and strength. Trenbolone is also a highly androgenic hormone, when compared with testosterone; its 5 times more androgenic than it. Testosterone measures at 100 while Tren measures at 500. Potent androgenic anabolics offer dry gains which is great for limiting water retention but don’t think that Tren is water retention free; as it is derived from a progesterone after all. Again as stated due to its great feed efficiency properties, it has potent nutrient partritioning effects. This means more glycogen for the muscle, and less glucose in the adipose tissues. If the compound has higher androgen binding, it will cause the androgen receptors within the fat cells to burn fat more efficiently. This could be alsoe from the rise in leptin with the simulatenous rise in androgens. There is evidence that shows when leptin rises while androgens rise, the body will burn fat at a faster rate to try to lower leptin.  One thing to remember with Tren is that it does lower thyroid hormones. This is why you will notice lets of bodybuilders use T3 or T4 while on cycle. You can also use a product like Alpha t2 which IMO works great for this reason and combining this with Need2slin will give even greater results . Add T3-pct to the pct or a good thyroid stimulating ” natural product”.
Other perks of Tren are that it does not aromatize into estrogen/estradiol nor does it convert to 5a reductase hormone also known as DHT. The lack of conversions prevents early aggravation of the prostate, estradiol based gynecomastia but that does not mean its gyno free which we will dive into further later.

The Drawbacks to Tren

One of the most intriguing yet not fully understood issues with Tren is its ability to lower thyroid hormones. So not only does it dramatically raise prolactin but it undeniably cuts thyroid levels in half. Even though Tren does not aromatize it can aggrevate the glandular tissue of the breast tissue which can result in what many refer to as Progesterone/Prolactin gyno. At first the nipples get puffy, then they start to hurt, nipples start to poke out. My friend was on a 120mg of it and boy he looked like he was in the mood so to speak all the time LMAO. Women would giggle at him because they thought he had no self control. When he took off his shirt, the nipples looked more like women’s nipples which is not pleasant at all. He got it taken care of with the advice that I gave him but had he not done so, eventually his nipples would start to excrete a gooey puss that would like milk. After all the rise in prolactin in women during pregnancy is what allows them to feed their child. I always advice using Provirone or materon when using tren. This will lower estroben and progestirone and Provirone always adds more fat lose to any cycle.

The mood swings that come from Tren are brutal. I have seen and heard people blacking out and carrying out violent acts because of the fact that they became so irritable. I can tell you that training your ass off in the gym and lowering can easily subside this side effect that is obtained from tren. I like to think of being tren is like having a 24/7 menstraul cycle HAHAHA. I have gone crazy on tren a few times my self nearly getting my self in a lot of trouble.. You will be moody and annoyed rather easily but it’s manageable. It used to make me laugh because there was this bouncer near where I lived that was always cycling Tren ace. Every time someone said something he did not agree with, his temper would flare and he would get so red which is from the elevated blood pressure, this has to do with a sudden rise in a fight or flight response. Basically your brain through norepinedrine tells your body to either do something about the situation or run for preserving one’s life. It’s the same reaction people with high testosterone will tend to display. A study showed that when men with high testosterone so aggressive faces, their heart rate elevated due to the increase in their fight or flight response. Remember Tren acts as testosterone; it is an androgen with both anabolic and ANDROGENIC properties.

Another uncomfortable side effect that comes with most androgens is high blood pressure resulting in loss of breath, increase in body temperature, rapid heartbeat, tightness of the chest, headaches. Since Tren is derivative from a progesterone, it increases water retention within the body, thus leading to the increase of blood pressure. No matter what androgen you take, there is always a chance of needing to go the Emergency Room due to elevated pressure, so make sure to take good preventive measures while on cycle.

Acne is common with Tren, as with most androgens; more so with wetter compounds such as Deca or Testosterone cypionate. Oil based esters are always going to give bad acne because you are INJECTING OIL INTO YOUR SKIN. HAHAHAHA!!  On tren you will sweat a ton due to its thermogenic/fat loss properties so acne chances increase from that aspect alone. One method I know that works is to take a warm shower which opens up the pours allowing all the bacteria from the skin to come out, then dry off next to a fan so that the pours close up. If you ever wrestled in high school and/or college, you know what I am talking about.

Here is the most common side effect that you hear with all Tren users besides mood swings. The NIGHT SWEATS! How many times have you twisted and turned to see that you have only been sleeping for an hour, or have not even fully went into REM. It’s funny because you read on forums that people experience waking up in a puddle of sweat while on Tren. The main reason why people sweat on Tren is the body is trying to get back to homeostasis as it sense that there is abnormal rate of progesterones in the body, a man’s natural physiology does not have such high progersterone count, so the body tries to work its magic but of course comes short resulting in a slight fever. This is why some people will wake up the next day with a fever of over 100 and feel like crap. Sleepless nights on Tren can also be because of the fat burning properties that it has, let’s say at some point during the day you had a grapefruit. The grapefruit contains a flavonoid called naringin that extends the half life of drugs. It does this by inhibiting the C450 enzyme, the same enzyme that is responsible for aromatization within the liver. So if you want to increase the effectiveness of your androgen, taking it with grapefruit would do the job but it will also increase the side effects. In other words you are feeling the after affects of Tren because of the naringin. Something to consider as well, would be injecting yourself with an infected needle, this can also lead to night sweat/ fever and so on.

Increased Anxiety is also real COMMON with Tren usage. It has neuro stimulative properties it. This is also the reason why aggression goes up. As stated before when norepinedrine goes up, your brain will either tell you to be scared or to fight. Aggression means that your brain decided to tell you to fight but if you are scared it’s because your body told you to run. Anxiety is derived from fear and denial, so if you are not confident in yourself in the given premise, the sudden rise in norepinedrine will cause your anxiety to steadily rise. Symptoms could be tremors, increased heart rate, decreased cardio, uneasiness, constant thinking, and lack of focus/concentration. Of course further anxiety can lead to a panic attack. Boy let me tell you from experience; panic attacks suck big time. Your body feels like something is wrong when in reality you are totally fine. I had so bad that my heart kept palpitating, and after every palpitation I would lose breath. I also would have slight bouts of increase in heart rate. I could hear my heart beating at all times. I also was sweating a crap ton. The only thing that helped me was releasing endorphins whether it be from comedy or pleasure. Unfortunately, I went to the hospital at one point and found nothing wrong with me which included an AKG test, and you know that is not cheap. I learned to ignore the symptoms and control stress which led to me to never experiencing it again. Increased anxiety while on Tren will also cause insomnia which blows big time. So if you see yourself staring into the dark sky at night for hours, expect it to last for a while. The body usually gets accustomed to Tren so this side should subside. If not you may need to find something to help you ease yourself to sleep.

Hair loss is common with all androgens, in theory Tren would cause hair loss as it like testosterone, so when the 19-nor metabolites reaches the scalp, it has a negative effect on the follicles. Remember the only difference between testosterone and Tren is the altered position at the 19^th position, so again hair loss is common even though Tren does not convert to DHT.

Also testicular atrophy is a GIVEN LMAO. This is stuff shuts you down harder than Test itself because of its potent androgen binding. Remember as explained before it’s 5 times more androgenic than Testosterone which means it binds 5 times stronger to the androgen receptors. The common belief is the harder the binding the harder the shutdown. It’s also a progesterone which means that it decreases dopamine which leads to an increase in prolactin. This leads a dramatic drop in testosterone and also a significant drop in libido. Dopamine is most responsible for your libido. Now keep in mind that the body knows that there is elevated androgens, so guess what happens, the body will also throw estradiol especially post cycle. Estrogen is the main inhibitor of testosterone. Your poor leydig cells take a double whammy from estrogen and prolactin. You will hear lot of guys laugh at the guy in the gym who has pea sized balls. Chances are he is on test and tren. I always advice running Aromasine 15mg every other day and Prami .5mg every 3 days with tren and combining this with Provirone or lasterone. This will help keep Prolactin and estrogen from getting to high as I said before. Add in Hcgenerate and Hcg alternated 4 weeks back and forth on both this will also help with shut down.

Forms of Tren

There are a couple of forms that Tren can be administered in order to gain the benefits of added muscle mass and strength.The two most common forms of Trenbolone are Trenbolone Acetate and Trenobolone  Ethanate. The way these esters work is that the plasma lipases cleave its ester group once it reaches the bloodstream leaving free trenbolone. Trenbolone and 17epi-trenbolone are both excreted through urine as conjugates that can be hydrolyzed with beta-glucuronidase. This would imply that trenbolone leaves the body as beta-glucuronides or as sulfates. Clearly the preffered form of Trenbolone is the acetate form as it only has a half of life 3 days meaning that it leaves the body fastest yet mg per mg it’s the strongest. Meaning you need less of it to get the intended benefits yet if side effects become too apparent, it would not take long for the sides to calm down after ceasing use.  Most people can be fine after 24 hours of ceasing use, but of course it also depends on dose and duration. Any form of Tren usually needs to be taken every other day to keep plasma blood levels concentrated.

Dosing

As for dosing Tren Ace, I recommend to start of with 60-90mg eod and see how it treats you. Honestly there is no point in exceeding 100mgs, you will notice that vets will use 120mgs every other day but its not needed to achieve those massive gains, only a slight difference. 8-12 weeks should be enough to gain mass and strength, Tren is rather toxic, for that reason I don’t recommend that one cycle it for longer periods of time. You can run tren Eth 200mg twice a week and Parapalon 300mg-400mg once a week.

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Kim, who holds a degree in art and is a government sales manager for an advanced security systems manufacturer, hired a personal trainer in her adopted home of Texas (she hails from Michigan originally), and set about changing her physique. What I think is important here is the fact that she sought out the help of an expert – despite having an IQ that puts her at the top of any class, she realized that she needed the help of an expert. That’s perfect, I think. You don’t become an expert overnight, no matter how bright you are, or what (*perhaps misleading) standardized tests tell you about your abilities.

The year 2010 found her divorced and facing Christmas alone after six years of marriage – so she filled her time taking advantage of the executive lifestyle: Oysters and Martinis, cigars, and partying. But soon after she decided to get in shape, she filled her time (and grocery cart) with sweet potatoes, steak, and traded the martinis for red wine.

Her nights were filled with reading books like The Paleo Diet, instead of smoking cigars with the boys.  Cinco de Mayo was two days before her contest, so she had water while her friends enjoyed tequila. And two days later, she took fourth place in her first bikini contest. Great story, and shows that some girls are more than a pretty face (although let’s be honest – she’s was probably the only M-member in the whole contest).

Side note: figure competitor Vanessa Adams Pierce also tested into Mensa, has been a member, and you may remember her as a Prolab sponsored athlete who appeared in a national ad campaign:

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If you don’t know who they are, you must have forgotten about the hormone they developed for dairy cows, that was ultimately found to be a carcinogen (caused cancer)…or the herbicide they developed that resulted in fifty lawsuits from people who alleged that they got cancer from it. Or the Fox News reporters who were fired for trying to expose the company…

Well, according to a recently published article, they’re back to their old tricks, and their latest weed killer lowers testosterone:

Sayer Ji, Contributing Writer
Activist Post

In a disturbing study published last month (Dec. 2011) in the Journal of Toxicology in Vitro, researchers found that Monsanto’s popular “weed killer” known as Roundup, which has already been linked to over 25 adverse health effects, is also capable of interfering with and/or harming the male reproductive system.

Researchers tested Roundup, a glyphosate-based herbicide, on mature rat testicular cells at a concentration range between 1 and 10,000 ppm, which they described as “the range in some human urine and in environment to agricultural levels.” They found that within 1 to 48 hours of Roundup exposure testicular (Leydig) cells were damaged or killed.

What is more disturbing is that even at a lower, presumably “non toxic” concentration of 1 ppm of Roundup, or glyphosate by itself, testosterone concentrations were observed to decrease by 35%.

Keep in mind that 1 ppm of Roundup is an infinitesimal concentration. Distilled water, as a reference point, contains between 5-10 ppm of dissolved solids. How can such a small concentration of Roundup/glyphosate cause such a profound disruption of biological activity in testicular cells? The phenomenon is known as endocrine disruption.

Endocrine disruptors are chemicals that interfere with the “synthesis, secretion, transport, binding, action, or elimination of natural hormones in the body that are responsible for development, behavior, fertility, and maintenance of homeostasis (normal cell metabolism),” and are capable of interfering with hormonal health even in minute concentrations. Whereas a higher concentration of Roundup might result in immediate cell death, a much lower one can alter the hormonal and genetic expression of that cell, perhaps taking it down the path towards pathological dysfunction, or even cancer.

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Also measured was their so-called “feel good” hormones after viewing scenes from the SitCom “The Big Bang Theory” – which proves once again that the British have no sense of humor, so I won’t belabor that point either….

Watching a four-minute erotic or aggressive video increases testosterone levels in rugby players and lead to improved strength and physical performance levels in training sessions that follow, according to a new study.

The finding is based on experiments involving 12 professional rugby players carried out by UK Sport, which is helping the British Olympic squad with scientific advice, the Daily Mail reported.

It is believed that the findings will be able to help coaches boost the effectiveness of training sessions.

In the study, the players were shown clips from five different categories of video.

A clip of US sitcom ‘The Big Bang Theory’ was used to convey ‘humour’, images of malnourished African children was used for ‘sadness’, exotic dancing conveyed ‘eroticism’, footage of training sessions by UFC star Brock Lesnar were classified as ‘motivational’, while images of rugby tackles were used for ‘aggression’.

Saliva samples were used to measure the players’ testosterone levels after watching the clips.

Significant increases in levels of the ‘feel good’ hormone were recorded after the players viewed the erotic, humorous, aggressive and motivational clips. Watching the control clip of starving children led to a significant decrease.

In training sessions that followed viewing the erotic and aggressive clips players also felt they had trained better.

“Rugby is a naturally combative sport and putting yourself in an aggressive frame of mind is quite important to how you perform,” Scott Drawer, head of research at UK Sport, told The Times.

Drawer added the caveat that any video clip’s effects on players was likely to be different, depending on the individual and the athlete.

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The structure and activity of Letrozole are very similar to that of Arimidex, and is prescribed for the same medical reasons. The FDA approved Letrozole for medical usage in 1997, where it is sold by the pharmaceutical company Novartis under the brand name of Femera. More specifically, United States prescribing guidelines for Letrozole recommend it to be used for the treatment of postmenopausal women with breast cancer. It is typically used as a second line of treatment after an estrogen receptor antagonist like tamoxifen has failed to obtain a favorable response. At times, Letro is prescribed as the first route of medication depending on the patients scenario. Letrozole was also used to induce ovulation in females, a study compared Clomid with Letro for inducing fertility on women. There was no difference in the overall rates of major and minor congenital malformations among newborns from mothers who conceived after letrozole or CC treatments. However, it appears that congenital cardiac anomaly is less frequent in the letrozole group. The concern that letrozole use for ovulation induction could be teratogenic is was documented not to be a concern.

Letrozole ( third generation) is a non steroidal selective third generation aromatse inhibitor which just like Arimadex will not give off androgenic effects. Its very similar to Arimadex which why they both are called Type2 non-sterodial competitive aromatase inhibitor. The main difference between Femara and Arimadex is that Femara is MORE potent. The MAX dosage for this AI is only 2.5mgs, by no means does one ever up the dosage, this will obliterate one’s estrogen by 98-99% within peak concentrations and is detrimental to cholesterol over pronlonged usage. Interestingly, it takes approximately 60 days to get a steady blood plasma level of letrozole once administration of the drug begins. This may necessitate that a user begin using the compound prior to beginning their cycle if they wish for the effects to be at full strength once their cycle begins. I never recommend it on testosterone since studies suggest that when estrogen is blocked while taking testosterone, HDL (good cholesterol) plummets to unsafe levels. Now the good thing about letro is that if estrogen is starting to irritate the glandular tissue of the breast tissue, letro if presented on time will clear up the issues at hand. For some reason people think that if gyno calcifies; Letro will be able to get rid of it, NOT TRUE, only surgery will get rid of gyno at that point. Be aware of your chest when running any compound as I have seen non-aromatizing compounds cause gyno in some people. Remember when using AAS, you are using an exogenous hormone that is not part of the body’s current chemistry and could cause issues such as gyo. I do not recommend using it during PCT as its detrimental to one’s libido and lipids since cholesterol production is already low. Run it preferable during cycle and please be careful with it since its extremely anti-estrogenic. When it comes to gyno any kind of Gyno My thinking is and always will be kill that shit as quickly as you can. Give it no chance to hang around. 2.5mg letro every day from the start and than taper down as it starts to work. If you are using Deca or other Nasralones and progesterone may be a part of the problem. Than you should add .5pm prami every day to that program too.Keep running them both until they start to work and than taper down as the problem goes away.

Strong treatment for Cancer, comparable to Nolvadex

In this random unbiased study, there were phase 3, double-blind trial of the treatment of hormone-receptor–positive breast cancer in postmenopausal women, in which women were randomly assigned to receive 5 years of tamoxifen monotherapy, 5 years of letrozole monotherapy, or 2 years of treatment with one agent followed by 3 years of treatment with the other. They compared the sequential treatments with letrozole monotherapy among 6182 women and also report a protocol-specified updated analysis of letrozole versus tamoxifen monotherapy in 4922 women. At a median follow-up of 71 months after randomization, disease-free survival was not significantly improved with either sequential treatment as compared with letrozole alone (hazard ratio for tamoxifen followed by letrozole, 1.05; 99% confidence interval [CI], 0.84 to 1.32; hazard ratio for letrozole followed by tamoxifen, 0.96; 99% CI, 0.76 to 1.21). There were more early relapses among women who were assigned to tamoxifen followed by letrozole than among those who were assigned to letrozole alone. The updated analysis of monotherapy showed that there was a nonsignificant difference in overall survival between women assigned to treatment with letrozole and those assigned to treatment with tamoxifen (hazard ratio for letrozole, 0.87; 95% CI, 0.75 to 1.02; P=0.08). The rate of adverse events was as expected on the basis of previous reports of letrozole and tamoxifen therapy. Among postmenopausal women with endocrine-responsive breast cancer, sequential treatment with letrozole and tamoxifen, as compared with letrozole monotherapy, did not improve disease-free survival. The difference in overall survival with letrozole monotherapy and tamoxifen monotherapy was not statistically significant. (ClinicalTrials.gov number, NCT00004205.)

Possibly used as pre TRT

Researchers did an experiment with 27 infertile men. The subjects were given a pill every day for six months that contained 2.5 mg letrozole. More than half of the males produced nearly no sperm cells. The treatment increased the males’ testosterone level and lowered their estradiol level. Both quantity and quality of sperm cells increased. No serious side effects were observed either. A few men developed mild headaches, but these were not serious enough for them to withdraw from the trial. In a Dutch study with obese men, the subjects’ testosterone level increased four times fold when they took a weekly pill containing 2.5 mg letrozole. In a Canadian case study, a daily 2.5 mg dose doubled the subjects’ testosterone levels. [Fertil Steril. 2009 Aug;92(2):829.e1-2.] In another clinical study, intravenous administration of Letrozole (2.5mcg for 28 days), Letrozole lowered Estrogen by 46% in the young men tested, and 62% in the older men. Something to note, Letrozole also significantly increased LH levels to a massive 339 and 323% in the young and the elderly, respectively and Testosterone by 146 and 99%, respectively. (J Clin Endocrinol Metab. 2005 Oct;90(10):5717-22. Epub 2005 Jul Comparative assessment in young and elderly men of the gonadotropin response to aromatase inhibition.) Letrozole was also able to produce a surge in LH response to Gonadatropin Releasing Hormone equal to a 152 and 52% increase from baseline in either young or older men, respectively. Due to its potent half life and potent strength to inhibit estradiol, men using it in this fashion should only take it once every 5 days or once every week.

Do not Run with Nolvadex

There is a study that shows taking 20mgs of Nolvadex will reduce plasma levels of Letrozole of about 30-38%. This quite normal with non-steroidal aromatase inhibitors, one should use a steroidal suicidal aromatase inhibitor while using a Selective Estrogen Receptor Modulator, especially during post cycle treatment.

Not easy on Bones/Joints

Like with most aromatase inhibitors it can be detrimental to bone and joint health, so one must drink plenty of water while using it along taking a sufficient amount of Calcium and Vitamin D. Vitamin D deficiency and insufficiency may contribute to musculoskeletal symptoms and bone loss observed in women taking aromatase inhibitors (AIs). This study was conducted to determine the prevalence of suboptimal vitamin D levels in women initiating adjuvant letrozole for breast cancer and to determine whether supplementation with 50,000 IU of vitamin D3 weekly could reduce musculoskeletal symptoms and fatigue in women who have suboptimal vitamin D levels. Sixty women about to begin an adjuvant AI were enrolled. Baseline 25OHD levels were obtained, and women completed symptom questionnaires. They were then started on letrozole, along with standard dose calcium and vitamin D. Four weeks later, women with baseline 25OHD levels 40 ng/ml were achieved in all 42 subjects who received 12 weeks of supplementation with 50,000 IU vitamin D3 weekly, with no adverse effects. After 16 weeks of letrozole, more women with 25OHD levels >66 ng/ml (median level) reported no disability from joint pain than did women with levels <66 ng/ml (52 vs. 19%; P = 0.026). Vitamin D deficiency and insufficiency are prevalent in post-menopausal women initiating adjuvant AI. Vitamin D3 supplementation with 50,000 IU per week is safe, significantly increases 25OHD levels, and may reduce disability from AI-induced arthralgias. (Breast Cancer Res Treat. 2010 Jan;119(1):111-8. Epub 2009 Aug 5)

Slight negative impact on Lipids

Due to the nature of its potent estrogen inhibiting capabilities, it can have a negative effect on one’s lipids. In the present study, we evaluated the effects of letrozole on the serum lipid profile in postmenopausal women with breast cancer. A total of 20 patients with breast cancer were treated with letrozole, 2.5 mg once daily. After an overnight fast, serum lipid parameters (total cholesterol, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, triglycerides, apolipoproteins A1, B and E and lipoprotein (a)) were measured before treatment and at 8 and 16 weeks afterwards. A significant increase in total cholesterol (P=0.05), LDL cholesterol (P<0.01) and apolipoprotein B levels (P=0.05) in the serum, as well as in the atherogenic risk ratios total cholesterol/HDL cholesterol (P<0.005) and LDL cholesterol/HDL cholesterol (P<0.005) was noticed after letrozole treatment. We conclude that letrozole administration in postmenopausal women with breast cancer has an unfavourable effect on the serum lipid profile. (Eur J Cancer. 2001 Aug;37(12):1510-3.)

Dosing

Letro can be taken every other day or every two to three days because of its long half life. It has the most occurring chance to cause rebound befor all other aromatase inhibitors due to the mechanism of action it has. I highly recommend that one slowly tapers down as they finish their use with Letrozole Than switch over to something like forma-stanzol for a few weeks.  Just remember guys this stuff is the big boy. The most powerful estrogen crushing weapon we have in our arsenal. LIke everything else the more powerful it is the more sides it comes with. I would never run letro long term and I would never use it as my On cycle preventive Ai. JUst use it to kill gyno as quick as you can with it and than get the hell off it. That is my advice.

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1. Cause and effect.
The law of cause and effect is one of the most powerful laws in the universe. I have put this law to the test over and over again and it has proven to be real and deserving of reverence and respect. Whatever we put out in the universe is what will come back to us…..If we want Happiness, peace, friendship and love then we should try to help others to be happy, we should be peaceful, we should be loving and we should be a friend. However Some times we must remember to see the gifts given to us and or opportunities placed before us. Letting these go simple out of fear of not living by the above laws can be costly. There is always a balance and times when we have to see things are meant to be the way they could be for us , the way we want them to be , the we we have wanted them to be… If the universe has given you the chance to have what you want then take it…..some things only come around once in a life time and when it comes to something that’s once in a life time
” nothing is more expensive than that missed opportunity” and although it may cost you a price what ever that price may be is worth paying because if you missed that ONE BIG CHANCE.. you may never ever get the chance again…..

2. the law of creation.
Yet another supernatural law I have had more then a few run ins with in my life. Life does not just happen!!! It requires that we are involved……… You can not sit back and put life on hold. You can not put off till tomorrow you must live every day of your life like there is no tomorrow!!!! The more you hold back now, the more you put off today for what ever excuse you have can and almost always will cause great things that could have been to pass you by. Your opportunities will be stolen from you that is how this law works. Its sort of a punishment for being afraid… fear is negative and negative energy draws negative results on your life. Energy of any kind in your life draws more of the same energy that is the law..

This law has to halves. The second halve also again has to do with the fact that “life does not just happen”…… EVERYTHING HAPPENS FOR A REASON!!!!!!!!!!!!!!!!!!! So when you look around your life. The people in it, the things going on within your life at this very moment… The things you have, the things you have done in the past up to what is going on right now in your life in the present has all happen because you made it happen. It took your Participation you got your self to where you are right now….. The universe has taken you to the very exact spot you are in life right now today because of every wish, every dream, every action, every thought, everything. Where you are today is not chance… its a direct result of universes reactions to your actions…. SO THINK ABOUT THAT>>>>> in everything you think about, think about that………… If your reading the words I am saying right now… Your life took you to this moment to read these words….. I hope you soke it all in and learn from it. When you harness the power of the universe you can move mountains. What you want will be yours….. Stop being afraid, stop second guessing, stop thinking you dont deserve or that what you want does not belong to you…………If its in your life and you want it its yours take it!!!!! unless of course its against the written laws of your country and or state lmao… Barring that if its in your ability Take it.. You keep what you kill……If some one else had it and the universe allowed you to take it than they made choices that showed the universe they did not deserve it, did not truly want it, or want it as bad as you did, but its no longer theirs……………. I dont sit and think every day GEE I feel so bad for So and so company that I been taking all there customers away… FUCK NO!!! I say to my self, than they should have treated them better, They should have worked harder, they lost them and no one is to blame for that but them. TOUGH NOOGIES I CARED MORE!!! I WANTED IT MORE!!! I WENT ABOVE AND BEYOND…

3. The law of Humanity
What you refuse to accept will continue for you…
If something is not good for you and you feel that in your heart and you know it. But you refuse to it except it… IT WILL ALWAYS ALWAYS ALWAYS CONTINUE FOR YOU!!!!!!!!!!!!!!!!!! UNDERSTAND THAT!!!!!!! what you refuse to except will always continue for you. I will say it again what you refuse to except will always continue for you……. SO if your with some one and lets say your hopping they will kind of just grow on you. Lets say their a nice person and you want to like them however you dont feel the connection… Or the attraction is not there in a physical way but your hoping some how it will be some day because well you just want it to be???? Smarten the hell up its never going to happen what you refuse to except will always continue… Except the fact. Embrace it, be honest and open to your self and except it… Than decide if you can except this fact and live with this fact for the rest of your life…..Because except it or not its always going to be especially if you cant except it, because you can not change what you have not excepted as a reality… Its called “settling” and we have all seen people do it. Just pretending something is what it really is not, Or is not what it really is will never change what it really is… Its a sad situation to watch a “self imprisoned heart” because that person refuses to except the reality that everyone else sees or they know to be true just for a hope that there heart or the other person heart (or actions or anything) may change some day…. Again this goes back to Law number 2 …There is no tomorrow!!!

Or another way this works is lets say the person you are with does not really love you at all. Or is not the kind of person you want them to be… Just know this… If you can not except something for what it really is than that something can never change…. No matter what that is….

4. the law of Growth….
Where ever you are in life, who ever is in your life, what ever spot you are in… YOU can not change any of it unless you change your self…. YOU!!! are the only thing you have complete 100% control over, you and only you, you must change. When you change then the people places and things around you will change with you………When we change who we are within our hearts and minds we change life around us!!! Its a fact!!! Notice how each and everyone of these laws all tie in together?

5. The law of responsibility…
This one is a mother fucker… This one I personally hate but can not deny (but some times its great indicator of why)… We Mirror what is around us and what is around us mirrors us. if there is something wrong in our lives it is because there is something wrong within us. YES!! and we all hate to not be able to point the finger at some one else don’t we, But its true…. We made wrong choices, we put out negative energy , we got our self where we are because the karma we put out .. Because of our actions and or our thoughts.

6. The law of connection.
This one is simple really.. Even if something we do seems small we must do it.. Many times when we think something is un important it can be one of the most important things ever because its the beginning of a process or the first step to something much greater. Everything in the universe is connected. Each step leads to the next. The 5th step is no less important than the first or the last step…… Do what you know you have to do and do it the very best you can no matter how unimportant you think it is….

7. The law of Focus..
It is imposable to have two mind sets.So lets take my life for instance. If In my industry I am always always focused on helping others as my goal. Than I can not also be focused on lesser things like greed. If I make serving others my focus then I can only be focused on this and not something else when I am out doing all that I do each day……..Focus what ever it is you do in a positive energy way. If I go out and I get involved in the negative talk I some times see about me. If I go out on the forums thinking negative about it the results I will get from this will be more negative. Even The things I think are negative I must find a way to think positive about them.

8. The law of giving and hospitality ……..My favorite of all the laws.

If you believe something to be true than at some point in your life you will be called on to demonstrate that truth!!! here is were we are called on to put our money where our mouth is…..
I have always believed I am in this industry to help people. That I do not care about money as much as I do people. And Anyone who has followed me long enough has seen me get called on many many times to prove my believes and words.So If you always profess to believe it like lets say you profess to believe you love some one. Well your going to get called on some day to prove it….. And maybe more than once. WHy is this law called the law of giving and hospitality than…Well many people give a lot of things. They give of them self, they give what they have, they give all kinds of things. Lots of people say they do a lot of giving and theysay they live a life of hospitality for others. But their true motives and reasons will be called on some day.. And they will be given a chance to prove what they have been proclaiming for so long. The universe always brings real motives to light sooner or later.

9. The law of hear and now…
Refusing to let go of what was will always prevent us from what could be!!!!!!!!!!!!!!!!!!!!! Holding on to old hopes and dreams will prevent us from having new ones. Hoping some day old relationships will come back again will hinder our ability to grow into new ones. Old thoughts, old dreams, old behaviors all of this will prevent us from having new ones….. If we refuse to allow the past to be the past then it will always prevent us from our future.If You have been hurt in the past. And you keep looking back at that hurt. Than it will forever prevent you from having a pain free future… No matter how many times something has happen in the past it is still the past and it does not have any effect on how it is going to be again in the future. Only if you keep reliving the past…

Well that person was with so and so before me
I used to be this or that
my last girl/boy friend did this or that
He used to be a trouble maker
That person used to be a thief

All to often we have been trained over and over again that the past is the only way to measure who, what, where, when , how the future is going to be. BULL SHIT!!!

Keeping in mind we really only have control over ourselves we have to remember that how our life was does not have to have any effect at all on how are life can be. Nor does how some one else life was have anything to do with how it could be now… If that person made that choice. People do change??? Now again this does not negate law 3 … what you refuse to except as the truth “now” will never change until you except it. Once excepted how it has been in the past does not have to be how it will be in the future. but you must always except how things are if there is to be any hope at all to change how they will be…… Its not confusing at all in fact its a master peace. How all of them are connected and all so powerful and true.

10. The law of change
History repeats its self until we learn the lessons we need to learn in order to change our paths. What has happen in the past will happen to us again in the future unless we have learned what it is we needed to learn…If your not happy with something and than you try something different and you are still not happy. Don’t think well I tried this and that so whats the use I mite as well just stick with what I have now… NO keep going and learn what it is you need to learn…

11. The law of patience and reword.
This one can tie in with law 10 above. Settling because you can not stand to wait can prevent you from having what you were meant to have, from learning the lessons you were meant to learn. True rewards come from doing what we feel strongly in our hearts to be what we really need to be doing. Than allowing the reword to come at its own time and not when we feel it should come…Remember this however does not negate fear!!! If we are not doing something out of fear then we are not waiting for the right reasons. If we are afraid our past will effect our future than we are holding back and waiting in a negative way. This will only result in negative.

12. The law of Significance and inspiration.
In other words you get out of something whatever you put into it. If you choice not to give then you will not get. This is common in relationships when one person says to the other. I am withholding this until I get that!! Again remember we only have control over our selves. So if in a negative way we hold back what we know is positive than all we will get out of it is what we are putting into it. Which happens to be negative!!

Or you are a man and you are attracted to a woman. Maybe you have feelings for her. Well if you never do anything about it you will never get anything out of it..If you are holding back out of fear this is negative so the results will be negative.  Also If you want to be a leader then you must invest into the people you are leading. If you put nothing into the people you lead than you will get nothing out of them.

Think about every law I have covered. What is the one common thing that combines them all together? ENERGY?? The energy that you have is ether negative or positive. So when you are faced with anything. Sit and think about what your energy is at that time. Is it negative? If it is than what you will get out of it is more negative. You thoughts, your mind is your own. No one has control over it. Just because the thought has entered your mind does not mean you have to except that thought the way it came to you.

As of right now these are the only laws I know of. I know there is many more. I will strive to learn all of them and live by them as much as I am able. When I make mistakes I will admit them however I will not dwell on them nor will I allow others to be in my life who do so. I know I will make mistakes I know I am not perfect But as each day passes I will be a better man tomorrow than I was today…………….When I see life place something in my path that I want I will do everything in my power to have it unless its taken out of my path… Its there for a reason so its mine. I will let no one tell me I can not have it, or It cant be done. These are stumbling blocks I will not allow to steel whats rightfully mine.

I will invest as much as I can into the people around me. I will give as much as I can to the people I lead. I will put in as much as I can to everything I am involved in and get everything out of it I can….

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