A phosphodiesterase type 5 inhibitor is a compound that blocks the degradation of phosphodiesterase type 5 on cyclic GMP in the smooth muscle cells lining of the blood vessels; which supplies the corpus cavernosum of the penis with blood flow. PDE-5 Ihibitiors such as Cialis are used in the treatment of erectile dysfunction, and were the first effective oral treatment available for this specific condition. PDE5 is also located in the arterial wall smooth muscle within the lungs, PDE5 inhibitors have also been used for the treatment of pulmonary hypertension, a disease in which blood vessels in the lungs become overflowed with fluid, usually due to the failure of the left ventricle of the heart. PDE5 inhibitors are clinically indicated for the treatment of erectile dysfunction. PDE5 inhibitors are primarily metabolized by the cytochrome P450 enzyme CYP3A4. The potential exists for adverse drug interactions with other drugs which inhibit or induce CYP3A4, including HIV protease inhibitors, ketoconazole, itraconazole, and other anti-hypertensive drugs such as Nitro-spray since it WILL lower blood pressure, which may result in a fatal drop of blood pressure. Taking PDE-5 Inhibitors with grapefruit juice or naringin will also prolong the effect of them, as grapefruit extract inhibits that enzyme from any other action but what is at state. (Adv. Cycl. Nucl. Res. 5:195-211, 1975.) Till this day, Sildenafil Citrate aka Viagra is the most popular PDE5 inhibitor, it was originally discovered during the search of a novel treatment for severe heart spasms. Studies in 2002 explored its potential for increasing the production of neurons after one has suffered as stroke. (Biochim. Biophys. Acta 284:220-226, 1972.)
A bit about Tadalafil Citrate
Tadalafil Citrate is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction under the name Cialis; and also under the brand name of Adcirca for the treatment of pulmonary arterial hypertension. It initially was developed by the ICOS, and then again refined and marketed world-wide by Lilly ICOS, LLC, the joint partnership company of ICOS Corporation and Eli Lilly & Company. Cialis tablets, in 5 mg, 10 mg, and 20 mg doses, are yellow, film-coated, and almond-shaped. The approved dose for pulmonary arterial hypertension is 40 mg once daily which would have me walking around the house with a hard on all day long for 3 days. LOLOLOL. The US approved Cialis for erectile Dysfunction treatment on November 21, 2003. Recently in May of 2009, Adcirca aka Cialis was passed as an official treatment for pulmonary arterial hypertension. Since it has the ability to stay potent for 3 days, people started to call it the Weekend Pill. For those who don’t get it, basically the dude would take Cialis Friday, and would be screwing from Friday Night to Sunday; to then get ready for the next work week. I personally feel its start to lose its potency after 48 hours from my personal experience. Since it lasts long, dosing is easier than with other PDE-5’s, which also means it acts smoother than the other PDE-5’s as well. I know from experience this holds true, 30 minutes after ingesting Viagra I have to be careful if I go out to public places, as anything could trigger the loyal soldier LOL. With Cialis I do not have that problem; on top of that I never get headaches with Cialis. With Viagra, there are times I have to keep drinking water and not strain so hard, or it will cause me to pass out within the 3 hours of taking it.
Cialis Increase testosterone
Seventy-four consecutive patients were treated on demand with sildenafil 50 mg and tadalafil 20 mg. The success in obtaining sexual intercourse was recorded and total (tT) and free testosterone (fT) levels were studied before and after 3 months of treatment. Basal level of tT and fT were at the bottom of the normal range and LH levels were at the top of the high normal range. After treatments, this endocrine pattern was reversed in both groups. However, the T increase in Sild-treated patients was significantly lower than in those treated with Tad (4·7 ± 2·7 vs. 5·1 ± 0·9, P < 0·001). fT levels followed a directly proportional pattern, while the inverse was found when LH production was studied. The average free testosterone levels increased from 59.9 pmol/L before treatment to 80.4 pmol/L after 3 months of treatment, the authors report. Total testosterone levels also rose (from 11.9 nmol/L to 16.3 nmol/L), while luteinizing hormone (LH) levels declined (from 4.7 IU/L to 2.7 IU/L). The intercourse rate reflected this effect: in fact, the Sild group showed a 4·9 ± 2·9/month full sexual intercourse rate while in the Tad group a significantly higher rate of sexual intercourse was found (6·9 ± 4·6/month, P = 0·04). However, drug consumption was comparable between the groups. (Clin Endocrinol, (Oxf) 2004;61:382–6.)
Researchers had participants perform three 30-second maximum output sprints to exhaustion and measured testosterone and cortisol responses to exercise. They found that only after Cialis and exercise did testosterone increase, however Cialis also increased cortisol levels which lets us know that you are going to want up your VitaminC intake to combat catabolism. The increase in cortisol also led to lowered levels of DHEA, a drop in DHEA will increase stress and drop immune system capabilities. The study demonstrates that Cialis increases the “stress” response to the body, just as caffeine does. Caffeine will also temporarily boost testosterone. Caffeine at high doses can cause NON SPECIFIC PDE inhibition. Remember also, an increase in dopamine from the testosterone should result in by product conversion to norepinepherine which would be responsible for the increase in alertness. (Int J Sport Nutr Exerc Metab, 2008 Apr;18(2):131-41.)
Now we come to what separates Cialis from other PDE in inhibitors. In this study, researchers discovered that the increase in testosterone from taking Cialis is mediated by a reduction in estrogen demonstration that Cialis may have anti-estrogenic properties. Research has shown consistently that T/estradiol ratio was associated with LONG TERM Cialis treatment. in LH levels did not rise from Cialis, indicating that Cialis did not directly stimulate testosterone production, but indirectly by lowering estrogen. This could explain why I noticed that I lose water retention while on Cialis, I also get a dry mouth which also is due to the rise Nitric Oxide. I also tend to urinate more often on it, I may have to do some blood work while on Cialis. (Greco EA, Pili M, Bruzziches R, Corona G, Spera G, Aversa A. Testosterone: Estradiol ratio changes associated with long-term tadalafil administration: A pilot study. J Sex Med, 2006;3:716–22.)
Cialis boosts endurance
I came upon a study that involved three maximum power sprints to determine if Cialis could increase anaerobic threshold. The study found no significant differences in peak power, average power or fatigue differences compared to the placebo, but it was noted was that Cialis decreased the time to reach peak power. The researchers concluded, “Cialis did not have an effect on peak power, but time to peak power output was reduced. Only to sports that need to reach maximum power output in a few seconds could Cialis administration be beneficial.” So those who want faster recovery in between sets will notice a difference while on Cialis, which is probably why guys get so pumped on it. If you are not taking long breaks like before due to the increase endurance, you will notice that you are pushing your limits, causing your muscles to be engorged with blood flow. (Br J Sports Med, 2008 Feb;42(2):130-3.)
Taking Cialis Preworkout seems like a great idea!
Nitric Oxide is one of the main signals for satellite cell activation. Nitric Oxide is an important regulator of hepatocyte growth factor (HGF), which is a cytokine with various cellular functions on muscle. A research study showed that stretched muscle-induced hypertrophy via release of HGF found that the release of HGF was dependent on NO concentrations. Researchers then measured HGF levels in serum after an intense bout of eccentric exercise. They found that the liver-derived HGF rose 19 percent approximately 4 hours post exercise, which resulted in an activation of satellite cells! It is possible that the observed rise in serum HGF showed that HGF could have been carried to the site of injury by immune cells rushing to the site of injury, which are increased in number during the inflammatory response to muscle damage. As we all know when muscle damage occurs, the overall amount of cytokines present in the body multiplies. The amount of HGF will be much more available while on Cialis, which in essence should increase muscle tissue. (Mol Biol Cell, 2000;11:1859 –1174.)
Another interesting study reported in the Journal of Muscle and Nerve was that Nitric Oxide actually was able to reverse the damaging effects of cortisol-induced satellite cell depletion. They found that Nitric Oxide had a dose-dependent effect on increasing satellite cell levels as well. If you use the citation you can see the graph, as too much will cause muscle damage and buch of other problems. This brings me to my next point, if you add creatine with Cialis you get a super increase of Satelite cells, this in turn will definitely aid in recovery while improving muscular endurance. A great cocktail conjuction would be N2KTS, 10-20mg of Cialis and 5 grams of creatine monohydrate/ Ancient Strength. (Muscle Nerve, 2008 Feb;37(2):203-9.)
I just want to remind you guys that when taking Cialis, be sure to start gradual. Start with 5mg, then work your way up by 5mg increments. THERE IS NO NEED TO INGEST MORE THAN 20MG’s within a 3 day period. Other things to take with it to spice up your love life include HCGenerate, iPT 141, Pramipexole, D-aspartic Acid, Unleashed/PostCycle and forma-stanzol.
The one thing that people forget about this drug is the fact that it does NOT stimulate libido. Yes we know that it will increase blood flow to the penis but it no way shape of form stimulates to get it on. In fact, in order for the penis to work, a hydrogen sulfide signal must be sent from the brain to the penis to allow the nitric oxide flow to begin, on top of that, androgens must be present so that the body can begin the mating process. The body works all in one motion, not in separate terms as you can see. If you stimulate one part, the rest IS affected by it in some way. I tell you what if you combine something like iPT 141 and Cialis, you will be going for rounds and rounds of sex.