What is Trenobolone?

 

Trenbolone is a classified schedule III drug in the United States; which means that it is illegal. It is from the 19-nor family of anabolic steroids just as deca is. The 19-nor stands for the fact that the testosterone molecule was changed at the 19th position to make it into the new and more potent compound. It was originally an anabolic androgic steroid developed and used by veterinarians on livestock to increase muscle growth and appetite and later would make its way to the chemical athlete’s world.  The farmers clearly knew that these anabolics were the key to bigger and better breeds, allowing for faster income as well.  On the average farmers sell cattle that have less than 28% EBF, they will not exhibit enough finish to reach a USDA quality grade of low choice. The majority of cattle need to have at least 28.5-29.5% EBF in order to grade to their genetic potential.

 

Therefore, all these factors need to be taken into consideration when choosing an effective implant (Trennobolone acetate) strategy which include feed costs, animal costs, quality grade, genetics, economic advantages of weight (live & carcass), production goals, and carcass goals. There are trade-offs to all the above and implants can help you achieve your goals and benefit you economically in all circumstances.

 

The chart from this link (http://www.depts.ttu.edu/afs/implantdb/dbhome/Revalor%20Tech%20Bulletin%2012.pdf) displays that cattle had the fastest rate of growth while on Finaflex pellets with the least amount of money spent as well. Now if you are a farmer chances are you are going to tell yourself, I am going to take this option instead of the old fashion grass fed way. The study also noted that when taking Tren with estradiol, the weight gain was more proficient. Of course bodybuilders don’t want to take estradiol, but taking tesostosterone will allow for aromatization which in turn will increase the body’s estradiol production leading to more muscle gain. This one of the reasons why the Test-Tren stack is so popular besides the fact that testosterone helps the impaired libido from Tren.

 

 

Benefits of Tren

In many people’s eyes, tren is pound for pound the strongest compound for pure gains and stacks well with anything; although some may argue that it’s a No No while on nanodrolone aka deca however I have ran both successfully with no more or less problems than running them separate . Trenbolone significantly increases nutrient efficiency along mineral/vitamin absorption. Feed efficiency is the measurement of how much of an animal diet is converted into meat, and the more consumption of food it takes to finalize this meat, the lower the value. On the other hand, the less food consumed by the animal to finalize the meat; the higher the value/efficiency. As mentioned in the study above, Cattle given trenbolone gained high quality weight without having their diet changed; leading to improved feed efficiency. This is music to the ears of every bodybuilder because Tren guarentees that every calorie you eat will go to some value of nutrition. This allows for better utlilization of the nutrition you intake to go to the muscles and organs of the body. This would explain why the cattle grew so rapidly while on Finaflex pellets.

Trenbolone is one of the few anabolic androgenic steroids that can lead to fat loss without change in diet, and it also has scholarly literature stating so.  This makes it perfect on a recomp as you will lose all fat needed but pack on dense muscle at the same time, don’t get me wrong; you can still use it for other goals including bulking and cutting.

Like most all anabolic androgenic steroids the Trenbolone hormone greatly promotes nitrogen retention in the muscles, increases red blood cell count and dramatically reduces and blocks glucocorticoid steroids aka the stress hormone cortisol; this hormone destroys muscle and increases fat storing hormones. This also means that you can do all the cardio you need to lose fat without having to worry about losing your muscle gains. Dieting can also place major stress on the mind and body leading to more cortisol, but Tren can help cease the cortisol release. Tren sounds ideal on a cut if you ask me. Increased nitrogen retention also means increased nutrient deliver to the muscles allowing for more glycogen retention. More glycogen retention leads to better workouts and a fuller look.

As is with nearly all anabolic androgenic steroids the Trenbolone hormone can greatly promote cell repair and regeneration, which will speed up the healing process in the body. The main reason why you experience growth on anabolics is because your recovery times goes up allowing you to become faster stronger. The more weight with frequency you can lift, the more and faster you will grow. One of the reasons why Tren is so good at increasing recovery time is the fact that it significantly increases the body’s natural production of the potent anabolic hormone IGF-1. Tren also causes muscle satellite cells to be more responsive to IGF-1 and other growth factors. The amount of DNA per muscle cell will also experience a significant increase. For these reasons adding Igf-lr3 into a tren cycle is a no brainer.

Trenbolone severely binds to the androgen receptors therefore increasing growth of muscle mass and melting fat away. This is important, because the stronger a steroid binds to the androgen receptor the better that steroid works at activating androgen receptor’s dependant mechanisms of muscle growth. There is also strong supporting evidence that androgens which bind very firmly to the androgen receptor also help in shedding fat. The androgen receptors are like locks and the androgens are like different keys. Some keys open the locks much better than others. This is does not mean that AR-binding is the only way that steroids work. There are anabolics that barely have any considerable binding to the AR and yet display great capability to build muscle and strength. Trenbolone is also a highly androgenic hormone, when compared with testosterone; its 5 times more androgenic than it. Testosterone measures at 100 while Tren measures at 500. Potent androgenic anabolics offer dry gains which is great for limiting water retention but don’t think that Tren is water retention free; as it is derived from a progesterone after all. Again as stated due to its great feed efficiency properties, it has potent nutrient partritioning effects. This means more glycogen for the muscle, and less glucose in the adipose tissues. If the compound has higher androgen binding, it will cause the androgen receptors within the fat cells to burn fat more efficiently. This could be alsoe from the rise in leptin with the simulatenous rise in androgens. There is evidence that shows when leptin rises while androgens rise, the body will burn fat at a faster rate to try to lower leptin.  One thing to remember with Tren is that it does lower thyroid hormones. This is why you will notice lets of bodybuilders use T3 or T4 while on cycle. You can also use a product like Alpha t2 which IMO works great for this reason and combining this with Need2slin will give even greater results . Add T3-pct to the pct or a good thyroid stimulating ” natural product”.
Other perks of Tren are that it does not aromatize into estrogen/estradiol nor does it convert to 5a reductase hormone also known as DHT. The lack of conversions prevents early aggravation of the prostate, estradiol based gynecomastia but that does not mean its gyno free which we will dive into further later.

 

The Drawbacks to Tren

One of the most intriguing yet not fully understood issues with Tren is its ability to lower thyroid hormones. So not only does it dramatically raise prolactin but it undeniably cuts thyroid levels in half. Even though Tren does not aromatize it can aggrevate the glandular tissue of the breast tissue which can result in what many refer to as Progesterone/Prolactin gyno. At first the nipples get puffy, then they start to hurt, nipples start to poke out. My friend was on a 120mg of it and boy he looked like he was in the mood so to speak all the time LMAO. Women would giggle at him because they thought he had no self control. When he took off his shirt, the nipples looked more like women’s nipples which is not pleasant at all. He got it taken care of with the advice that I gave him but had he not done so, eventually his nipples would start to excrete a gooey puss that would like milk. After all the rise in prolactin in women during pregnancy is what allows them to feed their child. I always advice using Provirone or materon when using tren. This will lower estroben and progestirone and Provirone always adds more fat lose to any cycle.

The mood swings that come from Tren are brutal. I have seen and heard people blacking out and carrying out violent acts because of the fact that they became so irritable. I can tell you that training your ass off in the gym and lowering can easily subside this side effect that is obtained from tren. I like to think of being tren is like having a 24/7 menstraul cycle HAHAHA. I have gone crazy on tren a few times my self nearly getting my self in a lot of trouble.. You will be moody and annoyed rather easily but it’s manageable. It used to make me laugh because there was this bouncer near where I lived that was always cycling Tren ace. Every time someone said something he did not agree with, his temper would flare and he would get so red which is from the elevated blood pressure, this has to do with a sudden rise in a fight or flight response. Basically your brain through norepinedrine tells your body to either do something about the situation or run for preserving one’s life. It’s the same reaction people with high testosterone will tend to display. A study showed that when men with high testosterone so aggressive faces, their heart rate elevated due to the increase in their fight or flight response. Remember Tren acts as testosterone; it is an androgen with both anabolic and ANDROGENIC properties.

Another uncomfortable side effect that comes with most androgens is high blood pressure resulting in loss of breath, increase in body temperature, rapid heartbeat, tightness of the chest, headaches. Since Tren is derivative from a progesterone, it increases water retention within the body, thus leading to the increase of blood pressure. No matter what androgen you take, there is always a chance of needing to go the Emergency Room due to elevated pressure, so make sure to take good preventive measures while on cycle.

Acne is common with Tren, as with most androgens; more so with wetter compounds such as Deca or Testosterone cypionate. Oil based esters are always going to give bad acne because you are INJECTING OIL INTO YOUR SKIN. HAHAHAHA!!  On tren you will sweat a ton due to its thermogenic/fat loss properties so acne chances increase from that aspect alone. One method I know that works is to take a warm shower which opens up the pours allowing all the bacteria from the skin to come out, then dry off next to a fan so that the pours close up. If you ever wrestled in high school and/or college, you know what I am talking about.

Here is the most common side effect that you hear with all Tren users besides mood swings. The NIGHT SWEATS! How many times have you twisted and turned to see that you have only been sleeping for an hour, or have not even fully went into REM. It’s funny because you read on forums that people experience waking up in a puddle of sweat while on Tren. The main reason why people sweat on Tren is the body is trying to get back to homeostasis as it sense that there is abnormal rate of progesterones in the body, a man’s natural physiology does not have such high progersterone count, so the body tries to work its magic but of course comes short resulting in a slight fever. This is why some people will wake up the next day with a fever of over 100 and feel like crap. Sleepless nights on Tren can also be because of the fat burning properties that it has, let’s say at some point during the day you had a grapefruit. The grapefruit contains a flavonoid called naringin that extends the half life of drugs. It does this by inhibiting the C450 enzyme, the same enzyme that is responsible for aromatization within the liver. So if you want to increase the effectiveness of your androgen, taking it with grapefruit would do the job but it will also increase the side effects. In other words you are feeling the after affects of Tren because of the naringin. Something to consider as well, would be injecting yourself with an infected needle, this can also lead to night sweat/ fever and so on.

Increased Anxiety is also real COMMON with Tren usage. It has neuro stimulative properties it. This is also the reason why aggression goes up. As stated before when norepinedrine goes up, your brain will either tell you to be scared or to fight. Aggression means that your brain decided to tell you to fight but if you are scared it’s because your body told you to run. Anxiety is derived from fear and denial, so if you are not confident in yourself in the given premise, the sudden rise in norepinedrine will cause your anxiety to steadily rise. Symptoms could be tremors, increased heart rate, decreased cardio, uneasiness, constant thinking, and lack of focus/concentration. Of course further anxiety can lead to a panic attack. Boy let me tell you from experience; panic attacks suck big time. Your body feels like something is wrong when in reality you are totally fine. I had so bad that my heart kept palpitating, and after every palpitation I would lose breath. I also would have slight bouts of increase in heart rate. I could hear my heart beating at all times. I also was sweating a crap ton. The only thing that helped me was releasing endorphins whether it be from comedy or pleasure. Unfortunately, I went to the hospital at one point and found nothing wrong with me which included an AKG test, and you know that is not cheap. I learned to ignore the symptoms and control stress which led to me to never experiencing it again. Increased anxiety while on Tren will also cause insomnia which blows big time. So if you see yourself staring into the dark sky at night for hours, expect it to last for a while. The body usually gets accustomed to Tren so this side should subside. If not you may need to find something to help you ease yourself to sleep.

Hair loss is common with all androgens, in theory Tren would cause hair loss as it like testosterone, so when the 19-nor metabolites reaches the scalp, it has a negative effect on the follicles. Remember the only difference between testosterone and Tren is the altered position at the 19th position, so again hair loss is common even though Tren does not convert to DHT.

Also testicular atrophy is a GIVEN LMAO. This is stuff shuts you down harder than Test itself because of its potent androgen binding. Remember as explained before it’s 5 times more androgenic than Testosterone which means it binds 5 times stronger to the androgen receptors. The common belief is the harder the binding the harder the shutdown. It’s also a progesterone which means that it decreases dopamine which leads to an increase in prolactin. This leads a dramatic drop in testosterone and also a significant drop in libido. Dopamine is most responsible for your libido. Now keep in mind that the body knows that there is elevated androgens, so guess what happens, the body will also throw estradiol especially post cycle. Estrogen is the main inhibitor of testosterone. Your poor leydig cells take a double whammy from estrogen and prolactin. You will hear lot of guys laugh at the guy in the gym who has pea sized balls. Chances are he is on test and tren. I always advice running Aromasine 15mg every other day and Prami .5mg every 3 days with tren and combining this with Provirone or lasterone. This will help keep Prolactin and estrogen from getting to high as I said before. Add in Hcgenerate and Hcg alternated 4 weeks back and forth on both this will also help with shut down.

Forms of Tren

There are a couple of forms that Tren can be administered in order to gain the benefits of added muscle mass and strength.The two most common forms of Trenbolone are Trenbolone Acetate and Trenobolone  Ethanate. The way these esters work is that the plasma lipases cleave its ester group once it reaches the bloodstream leaving free trenbolone. Trenbolone and 17epi-trenbolone are both excreted through urine as conjugates that can be hydrolyzed with beta-glucuronidase. This would imply that trenbolone leaves the body as beta-glucuronides or as sulfates. Clearly the preffered form of Trenbolone is the acetate form as it only has a half of life 3 days meaning that it leaves the body fastest yet mg per mg it’s the strongest. Meaning you need less of it to get the intended benefits yet if side effects become too apparent, it would not take long for the sides to calm down after ceasing use.  Most people can be fine after 24 hours of ceasing use, but of course it also depends on dose and duration. Any form of Tren usually needs to be taken every other day to keep plasma blood levels concentrated.

 

Dosing

 

 

As for dosing Tren Ace, I recommend to start of with 60-90mg eod and see how it treats you. Honestly there is no point in exceeding 100mgs, you will notice that vets will use 120mgs every other day but its not needed to achieve those massive gains, only a slight difference. 8-12 weeks should be enough to gain mass and strength, Tren is rather toxic, for that reason I don’t recommend that one cycle it for longer periods of time. You can run tren Eth 200mg twice a week and Parapalon 300mg-400mg once a week.

 

 

 

 

This month MENSA Bulletin featured an article about a member who was told by a friend that she’d never have the discipline to compete in a physique competition. As you might suspect, it’s a bad idea to tell people in the top 2% of intelligence what they can and can’t do…so after a mere 6 months of training, Kim Michalik found herself in a pair of clear heels and a bikini, at the NPC Texas Shredder.

Kim, who holds a degree in art and is a government sales manager for an advanced security systems manufacturer, hired a personal trainer in her adopted home of Texas (she hails from Michigan originally), and set about changing her physique. What I think is important here is the fact that she sought out the help of an expert – despite having an IQ that puts her at the top of any class, she realized that she needed the help of an expert. That’s perfect, I think. You don’t become an expert overnight, no matter how bright you are, or what (*perhaps misleading) standardized tests tell you about your abilities.

The year 2010 found her divorced and facing Christmas alone after six years of marriage – so she filled her time taking advantage of the executive lifestyle: Oysters and Martinis, cigars, and partying. But soon after she decided to get in shape, she filled her time (and grocery cart) with sweet potatoes, steak, and traded the martinis for red wine.

Her nights were filled with reading books like The Paleo Diet, instead of smoking cigars with the boys.  Cinco de Mayo was two days before her contest, so she had water while her friends enjoyed tequila. And two days later, she took fourth place in her first bikini contest. Great story, and shows that some girls are more than a pretty face (although let’s be honest – she’s was probably the only M-member in the whole contest).

Side note: figure competitor Vanessa Adams Pierce also tested into Mensa, has been a member, and you may remember her as a Prolab sponsored athlete who appeared in a national ad campaign:

 

Monsanto.

If you don’t know who they are, you must have forgotten about the hormone they developed for dairy cows, that was ultimately found to be a carcinogen (caused cancer)…or the herbicide they developed that resulted in fifty lawsuits from people who alleged that they got cancer from it. Or the Fox News reporters who were fired for trying to expose the company…

Well, according to a recently published article, they’re back to their old tricks, and their latest weed killer lowers testosterone:

 

Sayer Ji, Contributing Writer
Activist Post

In a disturbing study published last month (Dec. 2011) in the Journal of Toxicology in Vitro, researchers found that Monsanto’s popular “weed killer” known as Roundup, which has already been linked to over 25 adverse health effects, is also capable of interfering with and/or harming the male reproductive system.

Researchers tested Roundup, a glyphosate-based herbicide, on mature rat testicular cells at a concentration range between 1 and 10,000 ppm, which they described as “the range in some human urine and in environment to agricultural levels.” They found that within 1 to 48 hours of Roundup exposure testicular (Leydig) cells were damaged or killed.

What is more disturbing is that even at a lower, presumably “non toxic” concentration of 1 ppm of Roundup, or glyphosate by itself, testosterone concentrations were observed to decrease by 35%.

Keep in mind that 1 ppm of Roundup is an infinitesimal concentration. Distilled water, as a reference point, contains between 5-10 ppm of dissolved solids. How can such a small concentration of Roundup/glyphosate cause such a profound disruption of biological activity in testicular cells? The phenomenon is known as endocrine disruption.

Endocrine disruptors are chemicals that interfere with the “synthesis, secretion, transport, binding, action, or elimination of natural hormones in the body that are responsible for development, behavior, fertility, and maintenance of homeostasis (normal cell metabolism),” and are capable of interfering with hormonal health even in minute concentrations. Whereas a higher concentration of Roundup might result in immediate cell death, a much lower one can alter the hormonal and genetic expression of that cell, perhaps taking it down the path towards pathological dysfunction, or even cancer.

The connection between sex and increased testosterone levels is well documented, so I won’t belabor that point here. But a recent study conducted on a group of British rugby players indicates that watching a brief erotic clip (4 minutes of exitic dancing) can actually boost testosterone levels prior to training AND lead to an increase in athletic performance. For this group of rugby players, watching a clip of rugby tackling highlights also boosted their testosterone and performance, but where’s the fun in that?

Also measured was their so-called “feel good” hormones after viewing scenes from the SitCom “The Big Bang Theory” – which proves once again that the British have no sense of humor, so I won’t belabor that point either….

 

Watching a four-minute erotic or aggressive video increases testosterone levels in rugby players and lead to improved strength and physical performance levels in training sessions that follow, according to a new study.

The finding is based on experiments involving 12 professional rugby players carried out by UK Sport, which is helping the British Olympic squad with scientific advice, the Daily Mail reported.

It is believed that the findings will be able to help coaches boost the effectiveness of training sessions.

In the study, the players were shown clips from five different categories of video.

A clip of US sitcom ‘The Big Bang Theory’ was used to convey ‘humour’, images of malnourished African children was used for ‘sadness’, exotic dancing conveyed ‘eroticism’, footage of training sessions by UFC star Brock Lesnar were classified as ‘motivational’, while images of rugby tackles were used for ‘aggression’.

Saliva samples were used to measure the players’ testosterone levels after watching the clips.

Significant increases in levels of the ‘feel good’ hormone were recorded after the players viewed the erotic, humorous, aggressive and motivational clips. Watching the control clip of starving children led to a significant decrease.

In training sessions that followed viewing the erotic and aggressive clips players also felt they had trained better.

“Rugby is a naturally combative sport and putting yourself in an aggressive frame of mind is quite important to how you perform,” Scott Drawer, head of research at UK Sport, told The Times.

Drawer added the caveat that any video clip’s effects on players was likely to be different, depending on the individual and the athlete.

Letrozole

The structure and activity of Letrozole are very similar to that of Arimidex, and is prescribed for the same medical reasons. The FDA approved Letrozole for medical usage in 1997, where it is sold by the pharmaceutical company Novartis under the brand name of Femera. More specifically, United States prescribing guidelines for Letrozole recommend it to be used for the treatment of postmenopausal women with breast cancer. It is typically used as a second line of treatment after an estrogen receptor antagonist like tamoxifen has failed to obtain a favorable response. At times, Letro is prescribed as the first route of medication depending on the patients scenario. Letrozole was also used to induce ovulation in females, a study compared Clomid with Letro for inducing fertility on women. There was no difference in the overall rates of major and minor congenital malformations among newborns from mothers who conceived after letrozole or CC treatments. However, it appears that congenital cardiac anomaly is less frequent in the letrozole group. The concern that letrozole use for ovulation induction could be teratogenic is was documented not to be a concern.

Letrozole ( third generation) is a non steroidal selective third generation aromatse inhibitor which just like Arimadex will not give off androgenic effects. Its very similar to Arimadex which why they both are called Type2 non-sterodial competitive aromatase inhibitor. The main difference between Femara and Arimadex is that Femara is MORE potent. The MAX dosage for this AI is only 2.5mgs, by no means does one ever up the dosage, this will obliterate one’s estrogen by 98-99% within peak concentrations and is detrimental to cholesterol over pronlonged usage. Interestingly, it takes approximately 60 days to get a steady blood plasma level of letrozole once administration of the drug begins. This may necessitate that a user begin using the compound prior to beginning their cycle if they wish for the effects to be at full strength once their cycle begins. I never recommend it on testosterone since studies suggest that when estrogen is blocked while taking testosterone, HDL (good cholesterol) plummets to unsafe levels. Now the good thing about letro is that if estrogen is starting to irritate the glandular tissue of the breast tissue, letro if presented on time will clear up the issues at hand. For some reason people think that if gyno calcifies; Letro will be able to get rid of it, NOT TRUE, only surgery will get rid of gyno at that point. Be aware of your chest when running any compound as I have seen non-aromatizing compounds cause gyno in some people. Remember when using AAS, you are using an exogenous hormone that is not part of the body’s current chemistry and could cause issues such as gyo. I do not recommend using it during PCT as its detrimental to one’s libido and lipids since cholesterol production is already low. Run it preferable during cycle and please be careful with it since its extremely anti-estrogenic. When it comes to gyno any kind of Gyno My thinking is and always will be kill that shit as quickly as you can. Give it no chance to hang around. 2.5mg letro every day from the start and than taper down as it starts to work. If you are using Deca or other Nasralones and progesterone may be a part of the problem. Than you should add .5pm prami every day to that program too.Keep running them both until they start to work and than taper down as the problem goes away.

 

Strong treatment for Cancer, comparable to Nolvadex

In this random unbiased study, there were phase 3, double-blind trial of the treatment of hormone-receptor–positive breast cancer in postmenopausal women, in which women were randomly assigned to receive 5 years of tamoxifen monotherapy, 5 years of letrozole monotherapy, or 2 years of treatment with one agent followed by 3 years of treatment with the other. They compared the sequential treatments with letrozole monotherapy among 6182 women and also report a protocol-specified updated analysis of letrozole versus tamoxifen monotherapy in 4922 women. At a median follow-up of 71 months after randomization, disease-free survival was not significantly improved with either sequential treatment as compared with letrozole alone (hazard ratio for tamoxifen followed by letrozole, 1.05; 99% confidence interval [CI], 0.84 to 1.32; hazard ratio for letrozole followed by tamoxifen, 0.96; 99% CI, 0.76 to 1.21). There were more early relapses among women who were assigned to tamoxifen followed by letrozole than among those who were assigned to letrozole alone. The updated analysis of monotherapy showed that there was a nonsignificant difference in overall survival between women assigned to treatment with letrozole and those assigned to treatment with tamoxifen (hazard ratio for letrozole, 0.87; 95% CI, 0.75 to 1.02; P=0.08). The rate of adverse events was as expected on the basis of previous reports of letrozole and tamoxifen therapy. Among postmenopausal women with endocrine-responsive breast cancer, sequential treatment with letrozole and tamoxifen, as compared with letrozole monotherapy, did not improve disease-free survival. The difference in overall survival with letrozole monotherapy and tamoxifen monotherapy was not statistically significant. (ClinicalTrials.gov number, NCT00004205.)

Possibly used as pre TRT

Researchers did an experiment with 27 infertile men. The subjects were given a pill every day for six months that contained 2.5 mg letrozole. More than half of the males produced nearly no sperm cells. The treatment increased the males’ testosterone level and lowered their estradiol level. Both quantity and quality of sperm cells increased. No serious side effects were observed either. A few men developed mild headaches, but these were not serious enough for them to withdraw from the trial. In a Dutch study with obese men, the subjects’ testosterone level increased four times fold when they took a weekly pill containing 2.5 mg letrozole. In a Canadian case study, a daily 2.5 mg dose doubled the subjects’ testosterone levels. [Fertil Steril. 2009 Aug;92(2):829.e1-2.] In another clinical study, intravenous administration of Letrozole (2.5mcg for 28 days), Letrozole lowered Estrogen by 46% in the young men tested, and 62% in the older men. Something to note, Letrozole also significantly increased LH levels to a massive 339 and 323% in the young and the elderly, respectively and Testosterone by 146 and 99%, respectively. (J Clin Endocrinol Metab. 2005 Oct;90(10):5717-22. Epub 2005 Jul Comparative assessment in young and elderly men of the gonadotropin response to aromatase inhibition.) Letrozole was also able to produce a surge in LH response to Gonadatropin Releasing Hormone equal to a 152 and 52% increase from baseline in either young or older men, respectively. Due to its potent half life and potent strength to inhibit estradiol, men using it in this fashion should only take it once every 5 days or once every week.

Do not Run with Nolvadex

There is a study that shows taking 20mgs of Nolvadex will reduce plasma levels of Letrozole of about 30-38%. This quite normal with non-steroidal aromatase inhibitors, one should use a steroidal suicidal aromatase inhibitor while using a Selective Estrogen Receptor Modulator, especially during post cycle treatment.

Not easy on Bones/Joints

Like with most aromatase inhibitors it can be detrimental to bone and joint health, so one must drink plenty of water while using it along taking a sufficient amount of Calcium and Vitamin D. Vitamin D deficiency and insufficiency may contribute to musculoskeletal symptoms and bone loss observed in women taking aromatase inhibitors (AIs). This study was conducted to determine the prevalence of suboptimal vitamin D levels in women initiating adjuvant letrozole for breast cancer and to determine whether supplementation with 50,000 IU of vitamin D3 weekly could reduce musculoskeletal symptoms and fatigue in women who have suboptimal vitamin D levels. Sixty women about to begin an adjuvant AI were enrolled. Baseline 25OHD levels were obtained, and women completed symptom questionnaires. They were then started on letrozole, along with standard dose calcium and vitamin D. Four weeks later, women with baseline 25OHD levels 40 ng/ml were achieved in all 42 subjects who received 12 weeks of supplementation with 50,000 IU vitamin D3 weekly, with no adverse effects. After 16 weeks of letrozole, more women with 25OHD levels >66 ng/ml (median level) reported no disability from joint pain than did women with levels <66 ng/ml (52 vs. 19%; P = 0.026). Vitamin D deficiency and insufficiency are prevalent in post-menopausal women initiating adjuvant AI. Vitamin D3 supplementation with 50,000 IU per week is safe, significantly increases 25OHD levels, and may reduce disability from AI-induced arthralgias. (Breast Cancer Res Treat. 2010 Jan;119(1):111-8. Epub 2009 Aug 5)

Slight negative impact on Lipids

Due to the nature of its potent estrogen inhibiting capabilities, it can have a negative effect on one’s lipids. In the present study, we evaluated the effects of letrozole on the serum lipid profile in postmenopausal women with breast cancer. A total of 20 patients with breast cancer were treated with letrozole, 2.5 mg once daily. After an overnight fast, serum lipid parameters (total cholesterol, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, triglycerides, apolipoproteins A1, B and E and lipoprotein (a)) were measured before treatment and at 8 and 16 weeks afterwards. A significant increase in total cholesterol (P=0.05), LDL cholesterol (P<0.01) and apolipoprotein B levels (P=0.05) in the serum, as well as in the atherogenic risk ratios total cholesterol/HDL cholesterol (P<0.005) and LDL cholesterol/HDL cholesterol (P<0.005) was noticed after letrozole treatment. We conclude that letrozole administration in postmenopausal women with breast cancer has an unfavourable effect on the serum lipid profile. (Eur J Cancer. 2001 Aug;37(12):1510-3.)

Dosing

Letro can be taken every other day or every two to three days because of its long half life. It has the most occurring chance to cause rebound befor all other aromatase inhibitors due to the mechanism of action it has. I highly recommend that one slowly tapers down as they finish their use with Letrozole Than switch over to something like forma-stanzol for a few weeks.  Just remember guys this stuff is the big boy. The most powerful estrogen crushing weapon we have in our arsenal. LIke everything else the more powerful it is the more sides it comes with. I would never run letro long term and I would never use it as my On cycle preventive Ai. JUst use it to kill gyno as quick as you can with it and than get the hell off it. That is my advice.