Albuterol Albuterol sulfate is a selective fast butshort acting beta-2 adrenergic agonist,used for the relief of bronchospasm in conditions suchas asthma and chronic obstructivepulmonary disease. It is real similar in structure and mechanismto the well known cousin drug clenbuterol. Albuterol is readily available perprescription through a doctor within the United States. Clenbuterol is not FDAapproved which goes to show you it aint something to mess around with or takelightly. Albuterol is also sold under various brand names through a numberof other countries around the world. You will notice that Albuterol ismost commonly found in the form of a asthma inhaler, which is designed todisperse a measured amount of the drug immediately and directly to thebronchial tubes in a situation where one suffers a severe asthma attack. Theinhaler delivery of Albuterol provides the least amount of drug activitypossible, allowing the user to avoid unwanted cardiovascular side effects.Albuterol oral tablets are also available; however they do not provide the samecardio protective benefits that the inhalers are known to posses. Albuterol sulfate was introduced to the U.Sdrug market in 1968, sold under the brand name Ventolin. Albuterol sulfate has becomeone of the most popular drugs in recent history for its effectiveness and lackof side effects. This drug providesbenefits for athletes, bodybuilders, powerlifters and other individuals who areseeking to improve performance or their physical appearance. Albuterol is usuallyconsidered a fat burning agent in the bodybuilding community. Reason being isthat Albuterol has the ability to stimulate fat cells, increase lypolysis,decrease appetite, increase body temperature, as well as increasing basalmetabolic rate, increase cAMP, improve chlosterol while on cycle, and evenincrease strength. All of these factors, when combined with proper diet andtraining, would obviously help to increase the rate of fat loss in users.However the use of albuterol is not limited to simply fat loss. There isevidence that it can help to dramatically improve athletic performance as wellas helping to contribute to anabolism which well get into in a bit. However theperformance enhancing ability of albuterol is seemingly not limited to just strengthtraining. It was also shown that the times of users performing enduranceexercises significantly improved with the use of albuterol. It gets better; theseimprovements were completed without Albuterol negatively impacting the VO2respiratory breathing rate, heart rate or plasma free fatty acid and glycerolconcentration of users during the exercise conducted. Also the plasma lactateand potassium concentrations were altered constructively. This goes to showthat there is a reason why WADA banned Albuterol from athletic competition. Alittle bit about Beta-2 Receptors Beta receptors are found implantedin the cell’s outer phospholipid membrane. Beta receptors are stimulated by all the commonforms of stimulants such as ephedrine, DMMA and so on. The Beta receptors arebroken down into three subtypes: 1, 2, & 3, or more commonly seen as Beta-1, Beta-2, and Beta -3. Beta-1 is of no signifigance as Albuterol has noeffects on it. Beta-3 receptors tend not to really be biologically active inhumans as opposed to animals. So that leaves use with Beta-2 which is whereAlbuterol targets its stimulation of action upon. Stimulation of the Beta-2 receptors significantlystimulates the break down of fatty acids into the blood stream for use as fuel,thus causing a reduction in stored fat. When the blood flow increases so doesthe body’s temperature along heart rate. These actions in the body cause one tolose an appetite, which would explain why some people do not realize that theyhave gone the whole day without eating a stick of gum. I know some people wholiterally will have no urge to eat while on beta receptor agonists; they haveto literally force food down their mouth so that they receive sufficientdietary nutrient intake. Now we touch upon the anabolic aspects of Albuteroland other beta receptor agonists. Simply put is that Beta-agonists also stimulatea hormonal surge response that involves the activation of a compound calledcAMP aka cyclic-Adenosine Monophosphate. Once cAMP is stimulated, cAMPactivates calpistatin which is the inhibitor of calpain. Calpain is responsiblefor degrading protein within skeletal muscle. If you were to look at somestudies involving beta receptor agonists, especially Albuterol, you would seethat within an hour of ingesting a dose of it, testers bodily hormones roseincluding testosterone, thyroid hormones, cortisol, which is what also occurswhen you ingest forksolin. Forksolin is known to stimulate cAMP dramticallywhich is why for many years people who love supplements purchase Forksolin inbulk prior to their cutting and recomp cycles, reason being it provides greataid fat loss while aiding in maintaining muscle through the stimulation oftestosterone. cAMP also plays animportant role in controlling certain catecholamines secreted by the adrenalmedulla. Catecholamines have an inhibitory effect on muscle proteindegradation, Also crucial is that norepinephrine released from adrenergicterminals can in fact increase the rate of protein synthesis in oxidativemuscles, thereby leading to increased protein synthesis. As we all know greaterprotein synthesis leads to more anabolism which leads to more muscle gain.
Albuterol Outperforms Clen in the StrengthDepartment Clenbuterol does not match up withAlbuterol in the area of strength gains due to the fact that it dosedependently inhibits action potential firing within skeletal musclefibers. This is not directly stimulated byinnate Beta-2 stimulant activities. Reason being is that Clenbuterolblocked sodium currents in rat skeletal muscle fibers and in tsA201 cellstransfected with the human channel isoform, whereas Albuterol did not. Theeffects of clenbuterol were independent of beta-adrenoceptor stimulation.Instead, clenbuterol structure and physicochemical characteristics as well asblocking properties resembled those of local anesthetics, suggesting directbinding to the channels. (Mol Pharmacol. 2003Mar;63(3):659-70.)
Albuterol GREAT For Cholesterol!!!!!! This is because Albuterol showssignificant benefits to cholesterol as it works to lower total cholesterol,specifically LDL (the bad stuff) while at the same time elevating HDL. A study evaluated theeffects of a beta(2)-agonist, albuterol, on serum lipids and carbohydratehomeostasis in eight healthy nonsmoking men aged 24 to 61 years. Collection offasting blood samples was completed in duplicate on separate days at baseline,during 14 days of oral albuterol administration (Proventil Repetabs, 8 mg twicedaily; Schering Pharmaceuticals, Kenilworth, NJ) and during a 7-day washoutperiod. Carbohydrate homeostasis was evaluated using the minimal modeltechnique at the end of the baseline and albuterol periods. Fasting glucose andinsulin, intravenous glucose tolerance, acute insulin response to intravenousglucose (AIRg), insulin sensitivity (Si), and glucose effectiveness (Sg) werenot significantly changed during albuterol administration. Significantalterations (P < or = .02) were observed in total cholesterol ([TC]
9.1%+/ 2.5%), low-density lipoprotein cholesterol ([LDL-C] 15.0% +/ 2.9%), andhigh-density lipoprotein cholesterol ([HDL-C] +10.4% +/- 3.2%) concentrations,as well as the TC/HDL-C (-17.4% +/- 2.6%) and LDL-C/HDL-C (-22.9% +/- 2.4%)ratios. During washout, TC and LDL-C returned to baseline levels, whereas HDL-Cremained elevated by 5.8% +/- 2.4% (P < .05). Thus, albuterol administrationwas associated with favorable changes in the serum lipid profile without markedimpairment of glucose tolerance or its physiologic determinants. (Metabolism.1996 Jun;45(6):712-7) Another study I came upon was done on thirteenpatients for a total of 3 months. All patients had bronchial asthma and weretreated with 2 mg salbutamol three times daily (one patient with 4 mg threetimes daily). The concentrations of serum total cholesterol and LDL-cholesterolwere slightly but not statistically significantly higher after 3 months withsalbutamol than before the medication. The serum HDL-cholesterol andtriglyceride concentrations remained constant during the therapy. Serum freefatty acid levels decreased slightly but not significantly during the therapy.Treatment with salbutamol did not elevate plasma free fatty acid levels, whichmay have arrhythmic effects. The results indicate that beta 2-adrenergicstimulation has no effect on basal serum lipid levels. So besides beinganabolic, its also good for cholesterol sounds like a winner to me. This makesit ideal to take on cycle because we all know the negative affects AAS can havecholesterol, you literally get the best of both worlds while on Albuterol.
Usual dosing should start at around 1-2 4mg tabletsper day and will up the dosage as their individual tolerance allows for. Somepeople get up to 24mgs a day because of a high tolerance to the drug. Veterans will often take their temperature anduse an increase in temperature as a measure to what effect the drug is having.It is important to note that after 2-3 weeks, the receptors will become burnout to stimulation. I recommend 25mgs of Benedryl to up regulate the receptorsback into full gear which should allow you to take just one week off as opposedto the normal 2 on and 2 off protocol. Sides The most commonly noted side effects are fine tremor,anxiety,headache,muscle cramps, dry mouth,and palpitation. Other symptoms may include tachycardia,arrhythmia,flushing, myocardial ischemia, shaking of hands orjitters, shortness of breath, insomnia and impulsive behaviour. Rarelyoccurring, but of importance, are allergic reactions of paradoxicalbronchospasm,urticaria,angioedema,hypotension,and collapse. High doses may cause hypokalaemiawhich are of concern in patients with renal failureand those on certain diuretics and xanthinederivatives. High doses can also cause fatal heart complications due tooverstimulation of the CNS. Detectiontime of AlbuterolAlbuterol has a half life of about 4 hours which iswhy bodybuilders will take 3 divided dosages. Only slow releasing tabs willallow 12 hour dosing intervals. Urinary salbutamol concentrations arefrequently measured in competitive athletic commissions, for which a levels exceedingthat of 1000 μg/L is considered to be a form of cheating aka performanceenhancement. The window of detection for urine testing is on the order of just24 hours, given the relatively short elimination half-life of the drug. Albuterolboosts athletic performanceThe present study examined whetheroral short-term administration of salbutamol (Sal) aka Albuterol modifiesperformance and selected hormonal and metabolic variables during submaximalexercise. Eight recreational male athletes completed two cycling trials at80-85% peak O(2) consumption until exhaustion after either gelatin placebo(Pla) or oral Sal (12 mg/day for 3 wk) treatment, according to a double-blindand randomized protocol. Blood samples were collected at rest, after 5, 10, and15 min, and at exhaustion to determine growth hormone (GH), cortisol, testosterone,triiodothyronine (T 3), C peptide, free fatty acid (FFA), blood glucose,lactate, and blood urea values. Time of cycling was significantly increasedafter chronic Sal intake (Sal: 30.5 +/- 3.1 vs. Pla: 23.7 +/- 1.6 min, P <0.05). No change in any variable was found before cycling except a decrease inblood urea concentration and an increase in T(3) after Sal that remainedsignificant throughout the exercise test (P < 0.05). Compared with rest,exercise resulted in a significant increase in GH, cortisol, testosterone,T(3), FFAs, and lactate and a decrease in C peptide after both treatments withhigher exercise FFA levels and exhaustion GH concentrations after Sal (P <0.05). Sal but not Pla significantly decreased exercise blood glucose levels.From these data, short-term Sal intake did appear to improve performance duringintense sub maximal exercise with concomitant increase in substrateavailability and utilization, but the exact mechanisms involved need furtherinvestigation. (J Appl Physiol. 2000Aug;89(2):430-6.) Soif you are looking for a replacement to Clen, Albuterol is your go to drug asit is shorter acting which should yield less overall sides. It also providesgreater strength than clen, while providing great fat loss and being morebeneficial to one’s lipids. Anyone on cycle should really consider Albuterolover a lot of fat burners and that is a fact. Also remember that this drug willprovide gains in endurance and increase breathing capacity during training,unlike what some notice with Clen. Albuterol may not be as known as Clen but it is definitely what I call agolden nugget trapped in a sealed mine. I would reconsider Albuterol for your next physique improving cycle.